CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031907
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Isocitrate dehydrogenase [NADP] 
Protein Synonyms/Alias
  
Gene Name
 Idh 
Gene Synonyms/Alias
 CG7176; Dmel_CG7176 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
144ATITPDEKRVEEFNLacetylation[1]
178FREAIICKNVPRLVTacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
 NP_BIND 138 140 NADP (By similarity).
 NP_BIND 371 376 NADP (By similarity).
 REGION 157 163 Substrate binding (By similarity).
 METAL 313 313 Magnesium or manganese (By similarity).
 METAL 336 336 Magnesium or manganese (By similarity).
 BINDING 140 140 Substrate (By similarity).
 BINDING 145 145 NADP (By similarity).
 BINDING 172 172 Substrate (By similarity).
 BINDING 195 195 Substrate (By similarity).
 BINDING 321 321 NADP (By similarity).
 BINDING 389 389 NADP; via amide nitrogen and carbonyl  
Keyword
 Complete proteome; Magnesium; Manganese; Metal-binding; NADP; Oxidoreductase; Reference proteome; Tricarboxylic acid cycle. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 479 AA 
Protein Sequence
MFALRRTAAM MTSVHRQPHL SQAVFRANFA ISAADPKTHK ISMDNERMSA VSEHSSVVCS 60
PEQMAQKIKA GPVVDVLGDE MTRIIWDSIK SQLILPFLDI ELHTYDLGIE NRDKTEDQVT 120
IDCAEAIKKY NVGIKCATIT PDEKRVEEFN LKKMWKSPNG TIRNILGGTV FREAIICKNV 180
PRLVTGWQKP IVIGRHAHAD QYKAVDYVVP GPGKLTLTWK GTDGQVIDEV INDFKGPGIA 240
LGMFNTDDSI VDFAHASFKY ALDRKLPLYM STKNTILKKY DGRFKDIFED LYNKQYKKEY 300
EAAGIWYEHR LIDDMVAYAM KSEGGFVWAC KNYDGDVQSD SVAQGYGSLG LMTSVLLCPD 360
GKTVEAEAAH GTVTRHFRFY QQGKETSTNP IASIFAWTRG LLHRAKLDNN EPLKQFADTL 420
EQVCIDTIES GAMTKDLAIC IKGNINAVTR RDYQETFEFI NTLAKNLEGA LAKNAVAAK 479 
Gene Ontology
 GO:0005811; C:lipid particle; IDA:FlyBase.
 GO:0005739; C:mitochondrion; IDA:FlyBase.
 GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0006102; P:isocitrate metabolic process; IEA:InterPro.
 GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW. 
Interpro
 IPR019818; IsoCit/isopropylmalate_DH_CS.
 IPR004790; Isocitrate_DH_NADP.
 IPR024084; IsoPropMal-DH-like_dom. 
Pfam
 PF00180; Iso_dh 
SMART
  
PROSITE
 PS00470; IDH_IMDH 
PRINTS