| Tag | Content |
|---|
| CPLM ID | CPLM-016091 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | USP6 N-terminal-like protein |
Protein Synonyms/Alias | |
Gene Name | Usp6nl |
Gene Synonyms/Alias | Kiaa0019 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 267 | HHEKILNKFLSKLKQ | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex (By similarity). |
Sequence Annotation | DOMAIN 100 292 Rab-GAP TBC.
MOD_RES 389 389 Phosphoserine (By similarity).
MOD_RES 394 394 Phosphoserine (By similarity).
MOD_RES 544 544 Phosphoserine.
MOD_RES 574 574 Phosphoserine (By similarity).
MOD_RES 631 631 Phosphoserine (By similarity).
MOD_RES 644 644 Phosphoserine (By similarity).
MOD_RES 648 648 Phosphoserine (By similarity).
MOD_RES 662 662 Phosphoserine.
MOD_RES 669 669 Phosphoserine (By similarity).
MOD_RES 704 704 Phosphoserine (By similarity).
MOD_RES 717 717 Phosphotyrosine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Cytoplasmic vesicle; Golgi apparatus; GTPase activation; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 819 AA |
Protein Sequence | MIQVLQLVKE LVTPSRQKAA TAKEDSDQDV ALKLAQERAE IVAKYDRGRE GAEIEPWEDA 60
DYLVYKVTDR FGFLHEEELP YHNAAADRQK QLEIERTSKW LKMLKKWERY KNTEKFHRRI 120
YKGIPLQLRG EVWALLLEIP KMKEETRDLY SKLKHRARGC SPDIRQIDLD VNRTFRDHIM 180
FRDRYGVKQQ SLFHVLAAYS IYNTEVGYCQ GMSQITALLL MYMNEEDAFW ALVKLFSGPK 240
HAMHGFFVQG FPKLLRFQEH HEKILNKFLS KLKQHLDSQE IYTSFYTMKW FFQCFLDRTP 300
FRLNLRIWDI YIFEGERVLT AMSYTILKLH KKHLMKLSME ELVEFLQETL AKDFFFEDDF 360
VIEQLQVSMA ELKRAKLDLP EPGKEDEYPK KPLGQLPPES ACVNHLSNGQ RSVGRPSPKT 420
SSRREDGSPR KNHEHSPVHH SRNGTPERAG QSRRKSVDEG SKNLKHEAES QRKPSPGMQD 480
SSRHYNHAAA NQNSNAISNV RKEFMPKWRK PSDASAIERT TKYAVEGKSH SALPALPVAI 540
PGSAETRLPN SRQKMKALDG GEGKRGSNAS QYDNVPGGES EHGASAEEGP ERTHPHSPRK 600
HPEPSPSPPK VPNKFTFKVQ PPSHVRYPPQ LPEEDHRAAY PPSYSNPPVY HGNSPKHVPT 660
AHSGFVSTQI SPRPQINPSR RPYGSSLSVD TSPEKAYSRP TPVVLPSSRI EVLPIDMGAR 720
GYGSSGSPKN GQFILPPVDY LPENRKWSEV SYTYRPEMHG QSWTRDAHRS HLSNLPNYAA 780
FQHIPFQAHG LPEVSVDSPV RYKMSAAVED ASPPGYPYAG PSPSAHHYRN GEGLSVQESV 840
LL 842 |
Gene Ontology | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell. GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB. GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell. GO:0005097; F:Rab GTPase activator activity; ISS:UniProtKB. GO:0007030; P:Golgi organization; ISS:UniProtKB. GO:0035526; P:retrograde transport, plasma membrane to Golgi; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |