UniProt Accession

 ERD21_HUMAN; P24390; B2R6N4; Q54A39 

Genbank Protein ID

 X55885; AB097047; AK312647; CH471177; BC018778 

Genbank Nucleotide ID

 CAA39371.1; BAC77400.1; BAG35531.1; EAW52340.1; AAH18778.1 

Protein Name

 ER lumen protein retaining receptor 1 

Protein Synonyms/Alias

 KDEL endoplasmic reticulum protein retention receptor 1; KDEL receptor 1; Putative MAPK-activating protein PM23 

Gene Name

 KDELR1 

Gene Synonyms/Alias

 ERD2.1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
83	WLIYSKFKATYDGNH	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L. 

Sequence Annotation

  

Keyword

 Complete proteome; Endoplasmic reticulum; ER-Golgi transport; Membrane; Protein transport; Receptor; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 212 AA 

Protein Sequence

Gene Ontology

 GO:0005801; C:cis-Golgi network; IEA:Compara.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IDA:UniProtKB.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0016021; C:integral to membrane; TAS:ProtInc.
 GO:0005046; F:KDEL sequence binding; TAS:ProtInc.
 GO:0006886; P:intracellular protein transport; TAS:ProtInc.
 GO:0006621; P:protein retention in ER lumen; IEA:InterPro.
 GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW. 

Interpro

 IPR000133; ER_ret_rcpt. 

Pfam

 PF00810; ER_lumen_recept 

SMART

  

PROSITE

 PS00951; ER_LUMEN_RECEPTOR_1
 PS00952; ER_LUMEN_RECEPTOR_2 

PRINTS

 PR00660; ERLUMENR.