UniProt Accession

 SUCB1_HUMAN; Q9P2R7; B2RDE7; O95194; Q5T9Q4; Q5T9Q6; Q9NV21; Q9NVP7 

Genbank Protein ID

 AB035863; AK001458; AK001847; AK315513; AL157369; AL157369; CH471075; BC027587; AF058953 

Genbank Nucleotide ID

 BAA92873.1; BAA91703.1; BAA91939.1; BAG37894.1; CAI15149.1; CAI15153.1; EAX08777.1; AAH27587.1; AAC64396.1 

Protein Name

 Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial 

Protein Synonyms/Alias

 ATP-specific succinyl-CoA synthetase subunit beta; Renal carcinoma antigen NY-REN-39; Succinyl-CoA synthetase beta-A chain; SCS-betaA 

Gene Name

 SUCLA2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
78	VPKGYVAKSPDEAYA	acetylation	[1]
78	VPKGYVAKSPDEAYA	ubiquitination	[2]
89	EAYAIAKKLGSKDVV	ubiquitination	[3]
143	IGKKLFTKQTGEKGR	acetylation	[1]
143	IGKKLFTKQTGEKGR	ubiquitination	[3]
417	GTRVDDAKALIADSG	ubiquitination	[2]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Catalyzes the ATP-dependent ligation of succinate and CoA to form succinyl-CoA (By similarity). 

Sequence Annotation

 DOMAIN 61 288 ATP-grasp.
 MOD_RES 78 78 N6-acetyllysine.
 MOD_RES 84 84 Phosphotyrosine.
 MOD_RES 143 143 N6-acetyllysine.
 MOD_RES 279 279 Phosphoserine (By similarity).  

Keyword

 Acetylation; Alternative splicing; ATP-binding; Complete proteome; Disease mutation; Ligase; Mitochondrion; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Transit peptide; Tricarboxylic acid cycle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 463 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0004775; F:succinate-CoA ligase (ADP-forming) activity; TAS:UniProtKB.
 GO:0006105; P:succinate metabolic process; IEA:Compara.
 GO:0006781; P:succinyl-CoA pathway; NAS:UniProtKB.
 GO:0006099; P:tricarboxylic acid cycle; TAS:Reactome. 

Interpro

 IPR011761; ATP-grasp.
 IPR013650; ATP-grasp_succ-CoA_synth-type.
 IPR013815; ATP_grasp_subdomain_1.
 IPR013816; ATP_grasp_subdomain_2.
 IPR005811; CoA_ligase.
 IPR017866; Succ-CoA_synthase_bsu_CS.
 IPR005809; Succ_CoA_synthase_bsu.
 IPR016102; Succinyl-CoA_synth-like. 

Pfam

 PF08442; ATP-grasp_2
 PF00549; Ligase_CoA 

SMART

  

PROSITE

 PS50975; ATP_GRASP
 PS01217; SUCCINYL_COA_LIG_3 

PRINTS