CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019548
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein 
Protein Synonyms/Alias
  
Gene Name
 ALS2CR12 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
376AIVGNLEKMLQTKFAacetylation[1, 2]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773] 
Functional Description
  
Sequence Annotation
 MOD_RES 376 376 N6-acetyllysine.  
Keyword
 Acetylation; Alternative splicing; Coiled coil; Complete proteome; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 445 AA 
Protein Sequence
MYPNPLIYCT CWDPWNLGPR KLIKTPQLPR KNSTGSSKLT PLVPAPKNHN YLQPTKPVVS 60
PKMKIHSARQ EETNKSFYEV INVSPGYQLV RNREQISVTL GDEMFDRKKR WESEIPDKGR 120
FSRTNIISDL EEQISELTAI IEQMNRDHQS AQKLLSSEMD LRCAEMKQNF ENKNRELKEA 180
HEAELSELEN NYKAALKAEK LAAQEKLEEM GKEYKYLKNM FRTYQDSIYD EMEEKWSKQK 240
AKWKKDEKFE RENILLQQKK KMTKKFEMES GEEDKKINES CSAVFENFIQ EKEELLKQHQ 300
SDTLQLEELR KTKEVPWRRD QINRHWHDVL QQLLLMQVMQ EELHAQALIL ESLNTNLYYT 360
QLELQKEKAI VGNLEKMLQT KFAETEEKYK HTIQILTEEN IHLKQKIISK NEEICEGCSG 420
RLASITVSKD DSDTVQDGSK KGQES 445 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0043087; P:regulation of GTPase activity; NAS:UniProtKB. 
Interpro
 IPR026674; ALS2CR12.
 IPR026675; ALS2CR12_mammalian. 
Pfam
  
SMART
  
PROSITE
  
PRINTS