CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035117
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Acetyl-CoA carboxylase 1 
Protein Synonyms/Alias
  
Gene Name
 Acaca 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
212ENPDEGFKPSSGTVQacetylation[1]
608RIPLNVEKSIKKEMAacetylation[1]
1264INTPYVTKDLLQSKRacetylation[1]
1443YLTPQDYKRVSALNSacetylation[1]
1472KITDIIGKEEGLGAEacetylation[1]
1811PEGTVEIKFRKKDLVacetylation[1]
1819FRKKDLVKTMRRVDPacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Biotin; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2030 AA 
Protein Sequence
MIKASEGGGG KGIRKVNNAD DFPNLFRQVQ AEVPGSPIFV MRLAKQSRHL EVQILADQYG 60
NAISLFGRDC SVQRRHQKII EEAPAAIATP AVFEHMEQCA VKLAKMVGYV SAGTVEYLYS 120
QDGSFYFLEL NPRLQVEHPC TEMVADVNLP AAQLQIAMGI PLFRIKDIRM MYGVSPWGDA 180
PIDFENSAHV PCPRGHVIAA RITSENPDEG FKPSSGTVQE LNFRSNKNVW GYFSVAAAGG 240
LHEFADSQFG HCFSWGENRE EAISNMVVAL KELSIRGDFR TTVEYLIKLL ETESFQLNRI 300
DTGWLDRLIA EKVQAERPDT MLGVVCGALH VADVNLRNSI SNFLHSLERG QVLPAHTLLN 360
TVDVELIYEG IKYVLKVTRQ SPNSYVVIMN GSCVEVDVHR LSDGGLLLSY DGSSYTTYMK 420
EEVDRYRITI GNKTCVFEKE NDPSVMRSPS AGKLIQYIVE DGGHVFAGQC YAEIEVMKMV 480
MTLTAVESGC IHYVKRPGAA LDPGCVIAKM QLDNPSKVQQ AELHTGSLPQ IQSTALRGEK 540
LHRVFHYVLD NLVNVMNGYC LPDPFFSSKV KDWVERLMKT LRDPSLPLLE LQDIMTSVSG 600
RIPLNVEKSI KKEMAQYASN ITSVLCQFPS QQIANILDSH AATLNRKSER EVFFMNTQSI 660
VQLVQRYRSG IRGHMKAVVM DLLRQYLRVE TQFQNGHYDK CVFALREENK SDMNTVLNYI 720
FSHAQVTKKN LLVTMLIDQL CGRDPTLTDE LLNILTELTQ LSKTTNAKVA LRARQVLIAS 780
HLPSYELRHN QVESIFLSAI DMYGHQFCIE NLQKLILSET SIFDVLPNFF YHSNQVVRMA 840
ALEVYVRRAY IAYELNSVQH RQLKDNTCVV EFQFMLPTSH PNRMSFASNL NHYGMTHVAS 900
VSDVLLDNAF TPPCQRMGGM VSFRTFEDFV RIFDEVMGCF CDSPPQSPTF PESGHTSLYD 960
EDKVPRDEPI HILNVAIKTD GDIEDDRLAA MFREFTQQNK ATLVEHGIRR LTFLVAQKDF 1020
RKQVNCEVDQ RFHREFPKFF TFRARDKFEE DRIYRHLEPA LAFQLELNRM RNFDLTAIPC 1080
ANHKMHLYLG AAKVEVGTEV TDYRFFVRAI IRHSDLVTKE ASFEYLQNEG ERLLLEAMDE 1140
LEVAFNNTNV RTDCNHIFLN FVPTVIMDPS KIEESVRSMV MRYGSRLWKL RVLQAELKIN 1200
IRLTTTGKAI PIRLFLTNES GYYLDISLYK EVTDSRTAQI MFQAYGDKQG PLHGMLINTP 1260
YVTKDLLQSK RFQAQSLGTT YIYDIPEMFR QSLIKLWESM STQAFLPSPP LPSDILTYTE 1320
LVLDDQGQLV HMNRLPGGNE IGMVAWKMSL KSPEYPDGRD VIVIGNDITY RIGSFGPQED 1380
LLFLRASELA RAEGIPRIYV AANSGARIGL AEEIRHMFHV AWVDSEDPYK GYKYLYLTPQ 1440
DYKRVSALNS VHCEHVEDEG ESRYKITDII GKEEGLGAEN LRGSGMIAGE SSLAYDEIIT 1500
ISLVTCRAIG IGAYLVRLGQ RTIQVENSHL ILTGAGALNK VLGREVYTSN NQLGGIQIMH 1560
NNGVTHCTVC DDFEGVFTVL HWLSYMPKNV HSSVPLLNSK DPIDRIIEFV PTKAPYDPRW 1620
MLAGRPHPTQ KGQWLSGFFD YGSFSEIMQP WAQTVVVGRA RLGGIPVGVV AVETRTVELS 1680
VPADPANLDS EAKIIQQAGQ VWFPDSAFKT YQAIKDFNRE GLPLMVFANW RGFSGGMKDM 1740
YDQVLKFGAY IVDGLRECSQ PVMVYIPPQA ELRGGSWVVI DPTINPRHME MYADREIRGS 1800
VLEPEGTVEI KFRKKDLVKT MRRVDPVYIR LAERLGTPEL SPTERKELES KLKEREEFLI 1860
PIYHQVAVQF ADLHDTPGRM QEKGVINDIL DWKTSRTFFY WRLRRLLLED LVKKKIHSAN 1920
PELTDGQIQA MLRRWFVEVE GTVKAYVWDN NKDLVEWLEK QLTEEDGVRS VIEENIKYIS 1980
RDYVLKQIRS LVQANPEVAM DSIVHMTQHI SPTQRAEVVR ILSTMDSPST 2030 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0003989; F:acetyl-CoA carboxylase activity; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004075; F:biotin carboxylase activity; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0006084; P:acetyl-CoA metabolic process; IEA:Compara.
 GO:0006633; P:fatty acid biosynthetic process; IEA:Compara.
 GO:0055088; P:lipid homeostasis; IEA:Compara.
 GO:0044268; P:multicellular organismal protein metabolic process; IEA:Compara.
 GO:0051289; P:protein homotetramerization; IEA:Compara.
 GO:0001894; P:tissue homeostasis; IEA:Compara. 
Interpro
 IPR013537; AcCoA_COase_cen.
 IPR011761; ATP-grasp.
 IPR013815; ATP_grasp_subdomain_1.
 IPR013816; ATP_grasp_subdomain_2.
 IPR001882; Biotin_BS.
 IPR011764; Biotin_carboxylation_dom.
 IPR005482; Biotin_COase_C.
 IPR000089; Biotin_lipoyl.
 IPR000022; Carboxyl_trans.
 IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
 IPR011763; COA_CT_C.
 IPR011762; COA_CT_N.
 IPR011054; Rudment_hybrid_motif.
 IPR011053; Single_hybrid_motif. 
Pfam
 PF08326; ACC_central
 PF02785; Biotin_carb_C
 PF00364; Biotin_lipoyl
 PF01039; Carboxyl_trans
 PF02786; CPSase_L_D2 
SMART
 SM00878; Biotin_carb_C 
PROSITE
 PS50975; ATP_GRASP
 PS50979; BC
 PS00188; BIOTIN
 PS50968; BIOTINYL_LIPOYL
 PS50989; COA_CT_CTER
 PS50980; COA_CT_NTER
 PS00867; CPSASE_2 
PRINTS