| Tag | Content |
|---|
| CPLM ID | CPLM-000399 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Villin-like protein |
Protein Synonyms/Alias | |
Gene Name | VILL |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 248 | KDINQLQKANVRLYH | ubiquitination | [1] | | 320 | AVGFIQAKGYPTYTN | ubiquitination | [1] | | 362 | QKLGGRDKSIHVKLD | ubiquitination | [1] | | 760 | AVALQALKGSQDSSE | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Possible tumor suppressor. |
Sequence Annotation | REPEAT 22 74 Gelsolin-like 1.
REPEAT 146 186 Gelsolin-like 2.
REPEAT 263 307 Gelsolin-like 3.
REPEAT 401 450 Gelsolin-like 4.
REPEAT 521 561 Gelsolin-like 5.
REPEAT 624 665 Gelsolin-like 6.
DOMAIN 790 856 HP. |
Keyword | Actin capping; Actin-binding; Alternative splicing; Calcium; Complete proteome; Polymorphism; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 856 AA |
Protein Sequence | MDISKGLPGM QGGLHIWISE NRKMVPVPEG AYGNFFEEHC YVILHVPQSP KATQGASSDL 60
HYWVGKQAGA EAQGAAEAFQ QRLQDELGGQ TVLHREAQGH ESDCFCSYFR PGIIYRKGGL 120
ASDLKHVETN LFNIQRLLHI KGRKHVSATE VELSWNSFNK GDIFLLDLGK MMIQWNGPKT 180
SISEKARGLA LTYSLRDRER GGGRAQIGVV DDEAKAPDLM QIMEAVLGRR VGSLRAATPS 240
KDINQLQKAN VRLYHVYEKG KDLVVLELAT PPLTQDLLQE EDFYILDQGG FKIYVWQGRM 300
SSLQERKAAF SRAVGFIQAK GYPTYTNVEV VNDGAESAAF KQLFRTWSEK RRRNQKLGGR 360
DKSIHVKLDV GKLHTQPKLA AQLRMVDDGS GKVEVWCIQD LHRQPVDPKR HGQLCAGNCY 420
LVLYTYQRLG RVQYILYLWQ GHQATADEIE ALNSNAEELD VMYGGVLVQE HVTMGSEPPH 480
FLAIFQGQLV IFQERAGHHG KGQSASTTRL FQVQGTDSHN TRTMEVPARA SSLNSSDIFL 540
LVTASVCYLW FGKGCNGDQR EMARVVVTVI SRKNEETVLE GQEPPHFWEA LGGRAPYPSN 600
KRLPEEVPSF QPRLFECSSH MGCLVLAEVG FFSQEDLDKY DIMLLDTWQE IFLWLGEAAS 660
EWKEAVAWGQ EYLKTHPAGR SPATPIVLVK QGHEPPTFIG WFFTWDPYKW TSHPSHKEVV 720
DGSPAAASTI SEITAEVNNL RLSRWPGNGR AGAVALQALK GSQDSSENDL VRSPKSAGSR 780
TSSSVSSTSA TINGGLRREQ LMHQAVEDLP EGVDPARREF YLSDSDFQDI FGKSKEEFYS 840
MATWRQRQEK KQLGFF 856 |
Gene Ontology | GO:0015629; C:actin cytoskeleton; TAS:ProtInc. GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc. GO:0051693; P:actin filament capping; IEA:UniProtKB-KW. GO:0007010; P:cytoskeleton organization; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |