Tag | Content |
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CPLM ID | CPLM-009504 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | DNA-directed RNA polymerase II subunit RPB7 |
Protein Synonyms/Alias | RNA polymerase II subunit B7; DNA-directed RNA polymerase II subunit G |
Gene Name | Polr2g |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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27 | PNLLNTVKQKLFTEV | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA. Binds RNA (By similarity). |
Sequence Annotation | |
Keyword | Complete proteome; DNA-directed RNA polymerase; Nucleotidyltransferase; Nucleus; Reference proteome; RNA-binding; Transcription; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 172 AA |
Protein Sequence | MFYHISLEHE ILLHPRYFGP NLLNTVKQKL FTEVEGTCTG KYGFVIAVTT IDNIGAGVIQ 60 PGRGFVLYPV KYKAIVFRPF KGEVVDAVVT QVNKVGLFTE IGPMSCFISR HSIPSEMEFD 120 PNSNPPCYKT MDEDIVIQQD DEIRLKIVGT RVDKNDIFAI GSLMDDYLGL VS 172 |
Gene Ontology | GO:0005665; C:DNA-directed RNA polymerase II, core complex; ISS:UniProtKB. GO:0003899; F:DNA-directed RNA polymerase activity; IEA:UniProtKB-KW. GO:0004672; F:protein kinase activity; IEA:Compara. GO:0003723; F:RNA binding; IEA:UniProtKB-KW. GO:0006915; P:apoptotic process; IEA:Compara. GO:0006366; P:transcription from RNA polymerase II promoter; ISS:UniProtKB. |
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