CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038966
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Probable ATP-dependent RNA helicase DDX4 
Protein Synonyms/Alias
  
Gene Name
 Ddx4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
12DWEAEILKPHVSSYVacetylation[1]
436RLMDIIGKEKIGLKQacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 704 AA 
Protein Sequence
MGDEDWEAEI LKPHVSSYVP VFEKDKYSSG ANGDTFNRTS ASSSEMEDGP SGRDHFMRSG 60
FSSGRNLGNR DIGESSKRET TSTTGGFGRG KGFGNRGFLN NKFEEGDSSG FWKESTNDCE 120
DTQTRSRGFS KRGGYPDGND SEASGPFRRG GRGSFRGCRG GFGLGRPNKD SEYDQDQGSQ 180
RGGGLFGSRK PAASDSGSGD TFQSRSGNGR GGYKGLNEEV VTGSGKNSWK SEAEGGESSD 240
IQVQGPKVTY IPPPPPEDED SIFAHYQTGI NFDKYDTILV EVSGHDAPPA ILTFEEANLC 300
QTLNNNIAKA GYTKLTPVQK YSIPIVLAGR DLMACAQTGS GKTAAFLLPI LAHMMRDGIT 360
ASRFKELQEP ECIIVAPTRE LINQIYLEAR KFSFGTCVRA VVIYGGTQFG HSIRQIVQGC 420
NILCATPGRL MDIIGKEKIG LKQVKYLVLD EADRMLDMGF GPEMKKLISC PGMPSKEQRQ 480
TLLFSATFPE EIQRLAGEFL KSNYLFVAVG QVGGACRDVQ QSILQVGQYS KREKLVEILR 540
NIGDERTMVF VETKKKADFI ATFLCQEKIS TTSIHGDREQ REREQALGDF RCGKCPVLVA 600
TSVAARGLDI ENVQHVINFD LPSTIDEYVH RIGRTGRCGN TGRAISFFDT ESDNHLAQPL 660
VKVLSDAQQD VPAWLEEIAF SSYAPPSFSN STRGAVFASV DTRK 704 
Gene Ontology
 GO:0033391; C:chromatoid body; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0007141; P:male meiosis I; IEA:Compara.
 GO:0032880; P:regulation of protein localization; IEA:Compara.
 GO:0030317; P:sperm motility; IEA:Compara.
 GO:0007283; P:spermatogenesis; IEA:Compara. 
Interpro
 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR000629; RNA-helicase_DEAD-box_CS.
 IPR014014; RNA_helicase_DEAD_Q_motif. 
Pfam
 PF00270; DEAD
 PF00271; Helicase_C 
SMART
 SM00487; DEXDc
 SM00490; HELICc 
PROSITE
 PS00039; DEAD_ATP_HELICASE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER
 PS51195; Q_MOTIF 
PRINTS