CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022352
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kelch-like protein 28 
Protein Synonyms/Alias
 BTB/POZ domain-containing protein 5 
Gene Name
 KLHL28 
Gene Synonyms/Alias
 BTBD5 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
232RLPLLSVKFLTRLYEubiquitination[1]
251IRDDRTCKHLLNEALubiquitination[1]
283TRPRCAPKVLCAVGGubiquitination[1]
351RPGVTIRKHENSVECubiquitination[1]
412KYIPKIRKWQPVAPMubiquitination[1]
513WTVCRPMKEPRTGVGubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
 DOMAIN 35 102 BTB.
 REPEAT 284 331 Kelch 1.
 REPEAT 332 386 Kelch 2.
 REPEAT 387 433 Kelch 3.
 REPEAT 435 479 Kelch 4.
 REPEAT 480 526 Kelch 5.
 REPEAT 528 570 Kelch 6.  
Keyword
 Alternative splicing; Complete proteome; Kelch repeat; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 571 AA 
Protein Sequence
MDHTSPTYML ANLTHLHSEQ LLQGLNLLRQ HHELCDIILR VGDVKIHAHK VVLASVSPYF 60
KAMFTGNLSE KENSEVEFQC IDETALQAIV EYAYTGTVFI SQDTVESLLP AANLLQIKLV 120
LKECCAFLES QLDPGNCIGI SRFAETYGCR DLYLAATKYI CQNFEAVCQT EEFFELTHAD 180
LDEIVSNDCL NVATEETVFY ALESWIKYDV QERQKYLAQL LNSVRLPLLS VKFLTRLYEA 240
NHLIRDDRTC KHLLNEALKY HFMPEHRLSH QTVLMTRPRC APKVLCAVGG KSGLFACLDS 300
VEMYFPQNDS WIGLAPLNIP RYEFGICVLD QKVYVIGGIA TNVRPGVTIR KHENSVECWN 360
PDTNTWTSLE RMNESRSTLG VVVLAGELYA LGGYDGQSYL QSVEKYIPKI RKWQPVAPMT 420
TTRSCFAAAV LDGMIYAIGG YGPAHMNSVE RYDPSKDSWE MVASMADKRI HFGVGVMLGF 480
IFVVGGHNGV SHLSSIERYD PHQNQWTVCR PMKEPRTGVG AAVIDNYLYV VGGHSGSSYL 540
NTVQKYDPIS DTWLDSAGMI YCRCNFGLTA L 571 
Gene Ontology
  
Interpro
 IPR011705; BACK.
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ.
 IPR015916; Gal_Oxidase_b-propeller.
 IPR017096; Kelch-like_gigaxonin.
 IPR006652; Kelch_1. 
Pfam
 PF07707; BACK
 PF00651; BTB
 PF01344; Kelch_1 
SMART
 SM00875; BACK
 SM00225; BTB
 SM00612; Kelch 
PROSITE
 PS50097; BTB 
PRINTS