CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008146
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Amphiphysin 
Protein Synonyms/Alias
  
Gene Name
 AMPH 
Gene Synonyms/Alias
 AMPH1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
5***MADIKTGIFAKNacetylation[1]
15IFAKNVQKRLNRAQEacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton. 
Sequence Annotation
 DOMAIN 24 240 BAR.
 DOMAIN 622 695 SH3.
 MOD_RES 250 250 Phosphoserine (By similarity).
 MOD_RES 295 295 Phosphoserine (By similarity).
 MOD_RES 297 297 Phosphothreonine (By similarity).
 MOD_RES 506 506 Phosphoserine (By similarity).  
Keyword
 3D-structure; Alternative splicing; Cell junction; Coiled coil; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Membrane; Phosphoprotein; Polymorphism; Reference proteome; SH3 domain; Synapse. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 695 AA 
Protein Sequence
MADIKTGIFA KNVQKRLNRA QEKVLQKLGK ADETKDEQFE EYVQNFKRQE AEGTRLQREL 60
RGYLAAIKGM QEASMKLTES LHEVYEPDWY GREDVKMVGE KCDVLWEDFH QKLVDGSLLT 120
LDTYLGQFPD IKNRIAKRSR KLVDYDSARH HLEALQSSKR KDESRISKAE EEFQKAQKVF 180
EEFNVDLQEE LPSLWSRRVG FYVNTFKNVS SLEAKFHKEI AVLCHKLYEV MTKLGDQHAD 240
KAFTIQGAPS DSGPLRIAKT PSPPEEPSPL PSPTASPNHT LAPASPAPAR PRSPSQTRKG 300
PPVPPLPKVT PTKELQQENI ISFFEDNFVP EISVTTPSQN EVPEVKKEET LLDLDFDPFK 360
PEVTPAGSAG VTHSPMSQTL PWDLWTTSTD LVQPASGGSF NGFTQPQDTS LFTMQTDQSM 420
ICNLAESEQA PPTEPKAEEP LAAVTPAVGL DLGMDTRAEE PVEEAVIIPG ADADAAVGTL 480
VSAAEGAPGE EAEAEKATVP AGEGVSLEEA KIGTETTEGA ESAQPEAEEL EATVPQEKVI 540
PSVVIEPASN HEEEGENEIT IGAEPKETTE DAAPPGPTSE TPELATEQKP IQDPQPTPSA 600
PAMGAADQLA SAREASQELP PGFLYKVETL HDFEAANSDE LTLQRGDVVL VVPSDSEADQ 660
DAGWLVGVKE SDWLQYRDLA TYKGLFPENF TRRLD 695 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; TAS:ProtInc.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0008021; C:synaptic vesicle; TAS:ProtInc.
 GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0006897; P:endocytosis; TAS:ProtInc.
 GO:0007612; P:learning; IEA:Compara.
 GO:0007268; P:synaptic transmission; TAS:ProtInc.
 GO:0048488; P:synaptic vesicle endocytosis; IEA:Compara. 
Interpro
 IPR027267; AH/BAR-dom.
 IPR003005; Amphiphysin.
 IPR003017; Amphiphysin_1.
 IPR004148; BAR_dom.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 
Pfam
 PF03114; BAR
 PF07653; SH3_2 
SMART
 SM00721; BAR
 SM00326; SH3 
PROSITE
 PS51021; BAR
 PS50002; SH3 
PRINTS
 PR01251; AMPHIPHYSIN.
 PR01252; AMPHIPHYSIN1.
 PR00452; SH3DOMAIN.