UniProt Accession

 STX1A_MOUSE; O35526 

Genbank Protein ID

 D45208 

Genbank Nucleotide ID

 BAA28865.2 

Protein Name

 Syntaxin-1A 

Protein Synonyms/Alias

 Neuron-specific antigen HPC-1 

Gene Name

 Stx1a 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
12	TQELRTAKDSDDDDD	ubiquitination	[1]
46	EIRGFIDKIAENVEE	ubiquitination	[1]
70	ASPNPDEKTKEELEE	ubiquitination	[1]
94	NKVRSKLKSIEQSIE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. 

Sequence Annotation

 DOMAIN 192 254 t-SNARE coiled-coil homology.
 MOD_RES 14 14 Phosphoserine.
 MOD_RES 188 188 Phosphoserine; by DAPK1 (By similarity).  

Keyword

 Cell junction; Coiled coil; Complete proteome; Cytoplasmic vesicle; Direct protein sequencing; Exocytosis; Membrane; Neurotransmitter transport; Phosphoprotein; Reference proteome; Synapse; Synaptosome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 288 AA 

Protein Sequence

Gene Ontology

 GO:0042641; C:actomyosin; IEA:Compara.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043005; C:neuron projection; IDA:MGI.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0030141; C:secretory granule; IEA:Compara.
 GO:0030672; C:synaptic vesicle membrane; IDA:MGI.
 GO:0070044; C:synaptobrevin 2-SNAP-25-syntaxin-1a complex; IDA:MGI.
 GO:0070032; C:synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; ISO:MGI.
 GO:0019855; F:calcium channel inhibitor activity; IMP:MGI.
 GO:0001948; F:glycoprotein binding; ISO:MGI.
 GO:0000149; F:SNARE binding; IDA:MGI.
 GO:0017156; P:calcium ion-dependent exocytosis; IMP:MGI.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0045921; P:positive regulation of exocytosis; IEA:Compara.
 GO:0001956; P:positive regulation of neurotransmitter secretion; IEA:Compara.
 GO:0009629; P:response to gravity; IEA:Compara.
 GO:0016081; P:synaptic vesicle docking involved in exocytosis; IEA:Compara. 

Interpro

 IPR015709; Syntaxin-1.
 IPR006012; Syntaxin/epimorphin_CS.
 IPR006011; Syntaxin_N.
 IPR010989; t-SNARE.
 IPR000727; T_SNARE_dom. 

Pfam

 PF05739; SNARE
 PF00804; Syntaxin 

SMART

 SM00503; SynN
 SM00397; t_SNARE 

PROSITE

 PS00914; SYNTAXIN
 PS50192; T_SNARE 

PRINTS