CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021107
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Guanylate cyclase soluble subunit alpha-3 
Protein Synonyms/Alias
 GCS-alpha-3; GCS-alpha-1; Soluble guanylate cyclase large subunit 
Gene Name
 Gucy1a3 
Gene Synonyms/Alias
 Gucy1a1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
572SPHGEPIKMRIGLHSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
 DOMAIN 480 607 Guanylate cyclase.  
Keyword
 cGMP biosynthesis; Complete proteome; Cytoplasm; GTP-binding; Lyase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 691 AA 
Protein Sequence
MFCRKFKDLK ITGECPFSLL APGQVPKEPT EEVAGGSEGC QATLPICQYF PEKNAEGSLP 60
QRKTSRNRVY LHTLAESICK LIFPECERLN LALQRTLAKH KIEENRKSSE KEDLEKIIAE 120
EAIAAGAPVE ALKDSLGEEL FKICYEEDEH ILGVVGGTLK DFLNSFSTLL KQSSHCQEAE 180
RRGRLEDASI LCLDKDQDFL NVYYFFPKRT TALLLPGIIK AAARILYESH VEVSLMPPCF 240
RSDCTEFVNQ PYLLYSVHVK STKPSLSPGK PQSSLVIPAS LFCKTFPFHF MLDRDLAILQ 300
LGNGIRRLVN KRDFQGKPNF EEFFEILTPK INQTFSGIMT MLNMQFVIRV RRWDNSVKKS 360
SRVMDLKGQM IYIVESSAIL FLGSPCVDRL EDFTGRGLYL SDIPIHNALR DVVLIGEQAR 420
AQDGLKKRLG KLKATLEHAH QALEEEKKRT VDLLCSIFPS EVAQQLWQGQ IVQAKKFSEV 480
TMLFSDIVGF TAICSQCSPL QVITMLNALY TRFDQQCGEL DVYKVETIGD AYCVAGGLHR 540
ESDTHAVQIA LMALKMMELS NEVMSPHGEP IKMRIGLHSG SVFAGVVGVK MPRYCLFGNN 600
VTLANKFESC SVPRKINVSP TTYRLLKDCP GFVFTPRSRE ELPPNFPSDI PGICHFLDAY 660
HHQGPNSKPW FQDKDVEDGN ANFLGKASGI D 691 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0004383; F:guanylate cyclase activity; IEA:EC.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0006182; P:cGMP biosynthetic process; IMP:MGI.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0030828; P:positive regulation of cGMP biosynthetic process; IMP:MGI.
 GO:0008217; P:regulation of blood pressure; IMP:MGI.
 GO:0060087; P:relaxation of vascular smooth muscle; IMP:MGI.
 GO:0052565; P:response to defense-related host nitric oxide production; IMP:MGI. 
Interpro
 IPR001054; A/G_cyclase.
 IPR018297; A/G_cyclase_CS.
 IPR011645; Haem_no_assoc-bd.
 IPR011644; Heme_NO-bd. 
Pfam
 PF00211; Guanylate_cyc
 PF07700; HNOB
 PF07701; HNOBA 
SMART
 SM00044; CYCc 
PROSITE
 PS00452; GUANYLATE_CYCLASE_1
 PS50125; GUANYLATE_CYCLASE_2 
PRINTS