| Tag | Content |
|---|
| CPLM ID | CPLM-021823 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tropomodulin-2 |
Protein Synonyms/Alias | Neuronal tropomodulin; N-Tmod |
Gene Name | Tmod2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 23 | DEDELLGKLSEEELK | ubiquitination | [1] | | 81 | EKEALEQKDREDFVP | ubiquitination | [1] | | 216 | NIPIPTLKEFAKSLE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). |
Sequence Annotation | |
Keyword | Actin-binding; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 351 AA |
Protein Sequence | MALPFQKGLE KYKNIDEDEL LGKLSEEELK QLENVLDDLD PESATLPAGF RQKDQTQKAA 60
TGPFDREHLL MYLEKEALEQ KDREDFVPFT GEKKGRVFIP KEKPVETRKE EKVTLDPELE 120
EALASASDTE LYDLAAVLGV HNLLNNPKFD EETTNGEGRK GPVRNVVKGE KAKPVFEEPP 180
NPTNVEASLQ QMKANDPSLQ EVNLNNIKNI PIPTLKEFAK SLETNTHVKK FSLAATRSND 240
PVALAFAEML KVNKTLKSLN VESNFITGTG ILALVEALRE NDTLTEIKID NQRQQLGTAV 300
EMEIAQMLEE NSRILKFGYQ FTKQGPRTRV AAAITKNNDL VRKKRVEGDR R 351 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. GO:0030426; C:growth cone; IEA:Compara. GO:0007611; P:learning or memory; IMP:MGI. GO:0007270; P:neuron-neuron synaptic transmission; IMP:MGI. GO:0045745; P:positive regulation of G-protein coupled receptor protein signaling pathway; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |