UniProt Accession

 HEM1_YEAST; P09950; D6VSL3; E9P946 

Genbank Protein ID

 M26329; Z48612; AY723780; J03556; BK006938 

Genbank Nucleotide ID

 AAA34668.1; CAA88511.1; AAU09697.1; DAA12073.1 

Protein Name

 5-aminolevulinate synthase, mitochondrial 

Protein Synonyms/Alias

 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase 

Gene Name

 HEM1 

Gene Synonyms/Alias

 CYD1; YDR232W; YD9934.16 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
142	AMHKTIDKYGCGAGG	acetylation	[1]
337	MITGTLGKSFGSVGG	acetylation	[1]
351	GYVAASRKLIDWFRS	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

  

Sequence Annotation

 ACT_SITE 337 337 By similarity.
 BINDING 91 91 Substrate (By similarity).
 BINDING 204 204 Substrate (By similarity).
 BINDING 223 223 Substrate (By similarity).
 BINDING 256 256 Pyridoxal phosphate (By similarity).
 BINDING 284 284 Pyridoxal phosphate (By similarity).
 BINDING 334 334 Pyridoxal phosphate (By similarity).
 BINDING 366 366 Pyridoxal phosphate (By similarity).
 BINDING 367 367 Pyridoxal phosphate (By similarity).
 BINDING 452 452 Substrate (By similarity).
 MOD_RES 337 337 N6-(pyridoxal phosphate)lysine  

Keyword

 Acyltransferase; Complete proteome; Heme biosynthesis; Mitochondrion; Pyridoxal phosphate; Reference proteome; Transferase; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 548 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; IDA:SGD.
 GO:0003870; F:5-aminolevulinate synthase activity; IDA:SGD.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0006783; P:heme biosynthetic process; IMP:SGD.
 GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR010961; 4pyrrol_synth_NH2levulA_synth.
 IPR001917; Aminotrans_II_pyridoxalP_BS.
 IPR004839; Aminotransferase_I/II.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 

Pfam

 PF00155; Aminotran_1_2 

SMART

  

PROSITE

 PS00599; AA_TRANSFER_CLASS_2 

PRINTS