| Tag | Content |
|---|
| CPLM ID | CPLM-012156 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ras GTPase-activating-like protein IQGAP2 |
Protein Synonyms/Alias | |
Gene Name | IQGAP2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 520 | TQTGEASKLPYDVTT | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin. |
Sequence Annotation | DOMAIN 41 156 CH.
DOMAIN 594 627 WW.
DOMAIN 690 719 IQ 1.
DOMAIN 720 749 IQ 2.
DOMAIN 750 779 IQ 3.
DOMAIN 917 1150 Ras-GAP.
MOD_RES 16 16 Phosphoserine.
MOD_RES 1389 1389 Phosphoserine (By similarity). |
Keyword | 3D-structure; Alternative splicing; Calmodulin-binding; Complete proteome; Direct protein sequencing; Phosphoprotein; Polymorphism; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1575 AA |
Protein Sequence | MHSLPGVVAV GYINEAIDEG NPLRTLETLL LPTANISDVD PAHAQHYQDV LYHAKSQKLG 60
DSESVSKVLW LDEIQQAVDD ANVDKDRAKQ WVTLVVDVNQ CLEGKKSSDI LSVLKSSTSN 120
ANDIIPECAD KYYDALVKAK ELKSERVSSD GSWLKLNLHK KYDYYYNTDS KESSWVTPES 180
CLYKESWLTG KEIEAFWKGY KQRKEYMHRR QTFIDNTDSI VKIQSWFRMA TARKSYLSRL 240
QYFRDHNNEI VKIQSLLRAN KARDDYKTLV GSENPPLTVI RKFVYLLDQS DLDFQEELEV 300
ARLREEVVTK IRANQQLEKD LNLMDIKIGL LVKNRITLED VISHSKKLNK KKGGEMEILN 360
NTDNQGIKSL SKERRKTLET YQQLFYLLQT NPLYLAKLIF QMPQNKSTKF MDTVIFTLYN 420
YASNQREEYL LLKLFKTALE EEIKSKVDQV QDIVTGNPTV IKMVVSFNRG ARGQNTLRQL 480
LAPVVKEIID DKSLIINTNP VEVYKAWVNQ LETQTGEASK LPYDVTTEQA LTYPEVKNKL 540
EASIENLRRV TDKVLNSIIS SLDLLPYGLR YIAKVLKNSI HEKFPDATED ELLKIVGNLL 600
YYRYMNPAIV APDGFDIIDM TAGGQINSDQ RRNLGSVAKV LQHAASNKLF EGENEHLSSM 660
NNYLSETYQE FRKYFKEACN VPEPEEKFNM DKYTDLVTVS KPVIYISIEE IISTHSLLLE 720
HQDAIAPEKN DLLSELLGSL GEVPTVESFL GEGAVDPNDP NKANTLSQLS KTEISLVLTS 780
KYDIEDGEAI DSRSLMIKTK KLIIDVIRNQ PGNTLTEILE TPATAQQEVD HATDMVSRAM 840
IDSRTPEEMK HSQSMIEDAQ LPLEQKKRKI QRNLRTLEQT GHVSSENKYQ DILNEIAKDI 900
RNQRIYRKLR KAELAKLQQT LNALNKKAAF YEEQINYYDT YIKTCLDNLK RKNTRRSIKL 960
DGKGEPKGAK RAKPVKYTAA KLHEKGVLLD IDDLQTNQFK NVTFDIIATE DVGIFDVRSK 1020
FLGVEMEKVQ LNIQDLLQMQ YEGVAVMKMF DKVKVNVNLL IYLLNKKFYG K 1071 |
Gene Ontology | GO:0015629; C:actin cytoskeleton; TAS:ProtInc. GO:0005874; C:microtubule; IDA:UniProtKB. GO:0005902; C:microvillus; IEA:Compara. GO:0003779; F:actin binding; TAS:ProtInc. GO:0005095; F:GTPase inhibitor activity; TAS:ProtInc. GO:0005099; F:Ras GTPase activator activity; IEA:InterPro. GO:0032320; P:positive regulation of Ras GTPase activity; IEA:GOC. GO:0007165; P:signal transduction; TAS:ProtInc. GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |