UniProt Accession

 POPD1_MOUSE; Q9ES83; A2RS91; Q8C8L3 

Genbank Protein ID

 AF204174; AF124510; BC132018; BC132044; AK046765 

Genbank Nucleotide ID

 AAG23407.1; AAI32019.1; AAI32045.1; BAC32859.1 

Protein Name

 Blood vessel epicardial substance 

Protein Synonyms/Alias

 mBVES; Popeye domain-containing protein 1; Popeye protein 1 

Gene Name

 Bves 

Gene Synonyms/Alias

 Pop1; Popdc1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
122	KRPVKIEKELGGVYH	ubiquitination	[1]
166	QVYATEDKTSVDDRL	ubiquitination	[1]
272	NDPTLNDKKVKKLEP	ubiquitination	[1]
333	QRASAKMKPIEEGVE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3- mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading. 

Sequence Annotation

 CARBOHYD 2 2 N-linked (GlcNAc...) (Potential).
 CARBOHYD 30 30 N-linked (GlcNAc...) (Potential).  

Keyword

 Cell adhesion; Cell junction; Cell membrane; Complete proteome; Developmental protein; Glycoprotein; Membrane; Reference proteome; Tight junction; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 358 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IDA:UniProtKB.
 GO:0016328; C:lateral plasma membrane; IDA:UniProtKB.
 GO:0005923; C:tight junction; IDA:UniProtKB.
 GO:0005198; F:structural molecule activity; ISS:UniProtKB.
 GO:0090136; P:epithelial cell-cell adhesion; ISS:UniProtKB.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0040017; P:positive regulation of locomotion; IDA:UniProtKB.
 GO:0001921; P:positive regulation of receptor recycling; IDA:UniProtKB.
 GO:0043088; P:regulation of Cdc42 GTPase activity; IDA:UniProtKB.
 GO:0008360; P:regulation of cell shape; IDA:UniProtKB.
 GO:0032314; P:regulation of Rac GTPase activity; IDA:UniProtKB.
 GO:0034446; P:substrate adhesion-dependent cell spreading; IDA:UniProtKB.
 GO:0016192; P:vesicle-mediated transport; IDA:UniProtKB. 

Interpro

 IPR018490; cNMP-bd-like.
 IPR006916; Popeye_prot.
 IPR014710; RmlC-like_jellyroll. 

Pfam

 PF04831; Popeye 

SMART

  

PROSITE

  

PRINTS