CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018299
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Hexosaminidase D 
Protein Synonyms/Alias
 Beta-N-acetylhexosaminidase; Beta-hexosaminidase D; Hexosaminidase domain-containing protein; N-acetyl-beta-galactosaminidase 
Gene Name
 HEXDC 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
22DLKGAPPKVSYLSEIubiquitination[1]
172QEQNSTGKLCLSHMRubiquitination[1]
240GKVLLMQKYRRCGFPubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Has hexosaminidase activity. 
Sequence Annotation
 ACT_SITE 149 149 Proton donor (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Disulfide bond; Glycosidase; Hydrolase; Nucleus; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 486 AA 
Protein Sequence
MSGSTPFQMR LVHLDLKGAP PKVSYLSEIF PLFRALGANG LLIEYEDMFP YEGPLRLLRA 60
KYAYSPSEIK EILHLAGLNE LEVIPLVQTF GHMEFVLKHT AFAHLREVGS FPCTLNPHEA 120
ESLALVGAMI DQVLELHPGA QRLHIGCDEV YYLGEGEASR RWLQQEQNST GKLCLSHMRA 180
VASGVKARRP SVTPLVWDDM LRDLPEDQLA ASGVPQLVEP VLWDYTADLD VHGKVLLMQK 240
YRRCGFPQLW AASAFKGATG PSQAVPPVEH HLRNHVQWLQ VAGSGPTDSL QGIILTGWQR 300
YDHYSVLCEL LPAGVPSLAA CLQLLLRGGF DEDVKAKVEN LLGISSLEKT DPVRQAPCSP 360
PCPLLPLPFP RPWRQLFSAG LSAGRGPAPS LAATSLPLSH KSASICAALW MRCWRATGMS 420
LAGSAPTTAS GSSSTRSWFS TSSPQRSASW HSGAPSCRSW RLPCSWLSTR MPWRSGWRKT 480
CTPACSGCKL CCRTSARCLP PRCHPPALAG TLLRTPEGRA HARGLLLEAG GALHCQMAWA 540
IRAHVGVVPS GPAVSCPHSV PEGPGQPLGE RLENTEGSST GRPAL 585 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:EC.
 GO:0005975; P:carbohydrate metabolic process; IEA:InterPro. 
Interpro
 IPR015883; Glyco_hydro_20_cat-core.
 IPR013781; Glyco_hydro_catalytic_dom.
 IPR017853; Glycoside_hydrolase_SF. 
Pfam
 PF00728; Glyco_hydro_20 
SMART
  
PROSITE
  
PRINTS