UniProt Accession

 F5GY90_HUMAN; F5GY90 

Genbank Protein ID

 AP003391; AP003392 

Genbank Nucleotide ID

  

Protein Name

 Porphobilinogen deaminase 

Protein Synonyms/Alias

  

Gene Name

 HMBS 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
53	ILDTALSKIGEKSLF	ubiquitination	[1, 2]
57	ALSKIGEKSLFTKEL	acetylation	[2, 3]
57	ALSKIGEKSLFTKEL	ubiquitination	[1, 2]
70	ELEHALEKNEVDLVV	acetylation	[2]
98	FTIGAICKRENPHDA	ubiquitination	[1]
115	FHPKFVGKTLETLPE	ubiquitination	[1]
123	TLETLPEKSVVGTSS	ubiquitination	[1]
140	RAAQLQRKFPHLEFR	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 187 AA 

Protein Sequence

Gene Ontology

 GO:0004418; F:hydroxymethylbilane synthase activity; IEA:InterPro.
 GO:0033014; P:tetrapyrrole biosynthetic process; IEA:InterPro. 

Interpro

 IPR000860; 4pyrrol_synth_OHMeBilane_synth.
 IPR022417; Porphobilin_deaminase_N. 

Pfam

 PF01379; Porphobil_deam 

SMART

  

PROSITE

  

PRINTS

 PR00151; PORPHBDMNASE.