CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028473
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 LIM and SH3 domain protein 1 
Protein Synonyms/Alias
  
Gene Name
 Lasp1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
60EFEKNKGKGFSVVADacetylation[1]
60EFEKNKGKGFSVVADubiquitination[2]
76PELQRIKKTQDQISNacetylation[1, 3]
76PELQRIKKTQDQISNsuccinylation[3]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 89 AA 
Protein Sequence
MTLNMKNYKG YEKKPYCNAH YPKQSFTMVA DTPENLRLKQ QSELQSQVRY KEEFEKNKGK 60
GFSVVADTPE LQRIKKTQDQ ISNIKYHEE 89 
Gene Ontology
 GO:0030864; C:cortical actin cytoskeleton; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005925; C:focal adhesion; IDA:MGI.
 GO:0051015; F:actin filament binding; IDA:MGI.
 GO:0015075; F:ion transmembrane transporter activity; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR000900; Nebulin_35r-motif.
 IPR001781; Znf_LIM. 
Pfam
 PF00880; Nebulin 
SMART
  
PROSITE
 PS51216; NEBULIN 
PRINTS