CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024851
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sphingosine kinase 
Protein Synonyms/Alias
  
Gene Name
 Sphk1 
Gene Synonyms/Alias
 SPHK1a 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
149LLNPQGGKGKALQLFubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 504 AA 
Protein Sequence
ALLGTPKILR NSVGELQGPL GEKPPSRRDL VHCNPFLSGF VFLLDSPLLD FKKRCEDRDL 60
AAPGNDEGAH TAQGGGEGEP HGQSPDTLLG NTDKKLNAGA AVTSSSAGAA PVAPCQREPR 120
DLAMEPECPR GLLPRPCRVL VLLNPQGGKG KALQLFQSRV QPFLEEAEIT FKLILTERKN 180
HARELVCAEE LGHWDALAVM SGDGLMHEVV NGLMERPDWE TAIQKPLCSL PGGSGNALAA 240
SVNHYAGYEQ VTNEDLLINC TLLLCRRRLS PMNLLSLHTA SGLRLYSVLS LSWGFVADVD 300
LESEKYRRLG EIRFTVGTFF RLASLRIYQG QLAYLPVGTV ASKRPASTLV QKGPVDTHLV 360
PLEEPVPSHW TVVPEQDFLL VLVLLHTHLS SELFAAPMGR CEAGVMHLFY VRAGVSRAAL 420
LRLFLAMQKG KHMELDCPYL VHVPVVAFRL EPRSQRGVFS VDGELMVCEA VQGQVHPNYL 480
WMVCGSRDAP SGRDSRRGPP PEEP 504 
Gene Ontology
 GO:0005516; F:calmodulin binding; ISA:MGI.
 GO:0004143; F:diacylglycerol kinase activity; IEA:InterPro.
 GO:0003677; F:DNA binding; ISA:MGI.
 GO:0008481; F:sphinganine kinase activity; ISA:MGI.
 GO:0001568; P:blood vessel development; IGI:MGI.
 GO:0007420; P:brain development; IGI:MGI.
 GO:0006954; P:inflammatory response; IMP:MGI.
 GO:0008284; P:positive regulation of cell proliferation; IGI:MGI.
 GO:0007205; P:protein kinase C-activating G-protein coupled receptor signaling pathway; IEA:InterPro.
 GO:0032651; P:regulation of interleukin-1 beta production; IMP:MGI. 
Interpro
 IPR001206; Diacylglycerol_kinase_cat_dom. 
Pfam
 PF00781; DAGK_cat 
SMART
 SM00046; DAGKc 
PROSITE
 PS50146; DAGK 
PRINTS