| Tag | Content |
|---|
| CPLM ID | CPLM-004478 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Acetate operon repressor |
Protein Synonyms/Alias | |
Gene Name | iclR |
Gene Synonyms/Alias | b4018; JW3978 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 176 | LSEEQVTKLLHRKGL | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyruvate enhances promoter binding by stabilizing the tetrameric form. |
Sequence Annotation | DOMAIN 24 86 HTH iclR-type.
DOMAIN 101 272 IclR-ED.
DNA_BIND 46 65 H-T-H motif (Potential).
REGION 160 161 Glyoxylate binding.
REGION 239 241 Glyoxylate binding.
BINDING 212 212 Glyoxylate.
BINDING 222 222 Glyoxylate. |
Keyword | 3D-structure; Complete proteome; DNA-binding; Glyoxylate bypass; Reference proteome; Repressor; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 274 AA |
Protein Sequence | MVAPIPAKRG RKPAVATAPA TGQVQSLTRG LKLLEWIAES NGSVALTELA QQAGLPNSTT 60
HRLLTTMQQQ GFVRQVGELG HWAIGAHAFM VGSSFLQSRN LLAIVHPILR NLMEESGETV 120
NMAVLDQSDH EAIIIDQVQC THLMRMSAPI GGKLPMHASG AGKAFLAQLS EEQVTKLLHR 180
KGLHAYTHAT LVSPVHLKED LAQTRKRGYS FDDEEHALGL RCLAACIFDE HREPFAAISI 240
SGPISRITDD RVTEFGAMVI KAAKEVTLAY GGMR 274 |
Gene Ontology | GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW. GO:0006355; P:regulation of transcription, DNA-dependent; IMP:EcoCyc. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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