UniProt Accession

 THOC5_RAT; Q68FX7 

Genbank Protein ID

 BC079058 

Genbank Nucleotide ID

 AAH79058.1 

Protein Name

 THO complex subunit 5 homolog 

Protein Synonyms/Alias

 Fms-interacting protein 

Gene Name

 Thoc5 

Gene Synonyms/Alias

 Fmip 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
24	DGTPTEGKRNRSDTE	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Component the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex. Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development (By similarity). 

Sequence Annotation

 REGION 1 199 Interaction with THOC7 (By similarity).
 REGION 1 144 Interaction with CSF1R (By similarity).
 MOTIF 7 10 Nuclear localization signal (By
 MOD_RES 225 225 Phosphotyrosine (By similarity).
 MOD_RES 307 307 Phosphoserine (By similarity).
 MOD_RES 312 312 Phosphoserine (By similarity).
 MOD_RES 314 314 Phosphoserine (By similarity).
 MOD_RES 327 327 Phosphothreonine (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Differentiation; mRNA processing; mRNA splicing; mRNA transport; Nucleus; Phosphoprotein; Reference proteome; RNA-binding; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 682 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0045111; C:intermediate filament cytoskeleton; IEA:Compara.
 GO:0000445; C:THO complex part of transcription export complex; IEA:Compara.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0046784; P:intronless viral mRNA export from host nucleus; IEA:Compara.
 GO:0030224; P:monocyte differentiation; ISS:UniProtKB.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0045650; P:negative regulation of macrophage differentiation; IEA:Compara.
 GO:0060215; P:primitive hemopoiesis; ISS:UniProtKB.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR019163; THO_Thoc5. 

Pfam

 PF09766; FimP 

SMART

  

PROSITE

  

PRINTS