| Tag | Content |
|---|
| CPLM ID | CPLM-001369 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Leucine-rich repeat protein SHOC-2 |
Protein Synonyms/Alias | Protein soc-2 homolog; Protein sur-8 homolog |
Gene Name | Shoc2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 369 | MEHNRINKIPFGIFS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes (By similarity). |
Sequence Annotation | REPEAT 101 122 LRR 1.
REPEAT 124 145 LRR 2.
REPEAT 147 169 LRR 3.
REPEAT 170 191 LRR 4.
REPEAT 193 215 LRR 5.
REPEAT 216 237 LRR 6.
REPEAT 239 260 LRR 7.
REPEAT 262 283 LRR 8.
REPEAT 285 307 LRR 9.
REPEAT 308 329 LRR 10.
REPEAT 332 353 LRR 11.
REPEAT 356 377 LRR 12.
REPEAT 380 400 LRR 13.
REPEAT 403 424 LRR 14.
REPEAT 426 448 LRR 15.
REPEAT 449 470 LRR 16.
REPEAT 472 494 LRR 17.
REPEAT 495 516 LRR 18.
REPEAT 518 540 LRR 19.
REPEAT 542 563 LRR 20. |
Keyword | Complete proteome; Cytoplasm; Leucine-rich repeat; Nucleus; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 582 AA |
Protein Sequence | MSSSLGKEKD SKEKDPKVPS AKEREKESKA SGGFGKESKE KEPKAKGKDA KDGKKESSAA 60
QPGVAFSVDN TIKRPNPAPG TRKKSSNAEV IKELNKCREE NSMRLDLSKR SIHILPPSVK 120
ELTQLTELYL YSNKLQSLPA EVGCLVNLMT LALSENSLTS LPDSLDNLKK LRMLDLRHNK 180
LREIPSVVYR LDSLTTLYLR FNRITTVEKD IKNLPKLSML SIRENKIKQL PAEIGELCNL 240
ITLDVAHNQL EHLPKEIGNC TQITNLDLQH NDLLDLPDTI GNLSSLNRLG LRYNRLSAIP 300
RSLAKCSALE ELNLENNNIS TLPESLLSSL VKLNSLTLAR NCFQLYPVGG PSQFSTIYSL 360
NMEHNRINKI PFGIFSRAKV LSKLNMKDNQ LTSLPLDFGT WTSMVELNLA TNQLTKIPED 420
VSGLVSLEVL ILSNNLLKKL PHGLGNLRKL RELDLEENKL ESLPNEIAYL KDLQKLVLTN 480
NQLSTLPRGI GHLTNLTHLG LGENLLTHLP EEIGTLENLE ELYLNDNPNL HSLPFELALC 540
SKLSIMSIEN CPLSHLPPQI VAGGPSFIIQ FLKMQGPYRA MV 582 |
Gene Ontology | GO:0005634; C:nucleus; ISS:UniProtKB. GO:0000164; C:protein phosphatase type 1 complex; ISS:UniProtKB. GO:0019903; F:protein phosphatase binding; ISS:UniProtKB. GO:0046579; P:positive regulation of Ras protein signal transduction; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |