| Tag | Content |
|---|
| CPLM ID | CPLM-019922 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Beta-1-syntrophin |
Protein Synonyms/Alias | 59 kDa dystrophin-associated protein A1 basic component 1; DAPA1B; Syntrophin-2 |
Gene Name | Sntb1 |
Gene Synonyms/Alias | Snt2b1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 109 | PESISNQKRGVKVLK | ubiquitination | [1] | | 140 | KMPILISKIFKGLAA | ubiquitination | [1] | | 184 | QALKRAGKEVLLEVK | ubiquitination | [1] | | 191 | KEVLLEVKYMREATP | ubiquitination | [1] | | 246 | DRKSIPLKMCYVTRN | ubiquitination | [1] | | 272 | EIHSPDAKHTVILRS | ubiquitination | [1] | | 280 | HTVILRSKDSATAQA | ubiquitination | [1] | | 313 | DIREQLGKTGIAGSR | ubiquitination | [1] | | 338 | KVPGESEKQWKPALV | ubiquitination | [1] | | 341 | GESEKQWKPALVVLT | ubiquitination | [1] | | 386 | LVHSGPGKGSPQAGM | ubiquitination | [1] | | 404 | FATRTGTKQGIETHL | ubiquitination | [1] | | 484 | IIQSPYEKLKMSSDD | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. |
Sequence Annotation | DOMAIN 18 297 PH 1.
DOMAIN 111 194 PDZ.
DOMAIN 321 432 PH 2.
DOMAIN 481 537 SU.
REGION 517 537 Calmodulin-binding (By similarity).
MOD_RES 2 2 N-acetylalanine (By similarity).
MOD_RES 71 71 Phosphoserine.
MOD_RES 73 73 Phosphothreonine.
MOD_RES 86 86 Phosphoserine.
MOD_RES 213 213 Phosphothreonine.
MOD_RES 218 218 Phosphoserine.
MOD_RES 235 235 Phosphoserine.
MOD_RES 388 388 Phosphoserine (By similarity). |
Keyword | Acetylation; Actin-binding; Alternative splicing; Calcium; Calmodulin-binding; Cell junction; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 537 AA |
Protein Sequence | MAVAAAAVAA PAGGGGARAQ RSGLLEVLVR DRWHKVLVNL SEDALVLSCE EGAAAYNGIG 60
AATNGSFCRG SGTGHPVPGV AQAPDSPAGV RTAFTDLPEQ VPESISNQKR GVKVLKQELG 120
GLGISIKGGK ENKMPILISK IFKGLAADQT QALYVGDAIL SVNGADLRDA THDEAVQALK 180
RAGKEVLLEV KYMREATPYV KKGSPVSEIG WETPPPESPR LGGGSAEPLS SQSFSFHRDR 240
KSIPLKMCYV TRNMTLADPE NRQLEIHSPD AKHTVILRSK DSATAQAWFS AIHSNAGDLL 300
TRVVADIREQ LGKTGIAGSR EIRHLGWLAE KVPGESEKQW KPALVVLTEK DLLIYDSMPR 360
RKEAWFSPVH SYPLLATRLV HSGPGKGSPQ AGMDLSFATR TGTKQGIETH LFRAEISRDL 420
SHWTRSIVQG CHNSAELTAE ITTACTYRNQ ECRLTIHYDN GFSISTEPQD GAFPKTIIQS 480
PYEKLKMSSD DGIRMLYLDF GGKEGEIQLD LHSCPKPIVF IIHSFLSAKI TRLGLVA 537 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |