CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030860
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 CUGBP Elav-like family member 2 
Protein Synonyms/Alias
 cDNA FLJ51739, highly similar to Homo sapiens CUG triplet repeat, RNA binding protein 2 (CUGBP2), transcript variant 2, mRNA 
Gene Name
 CELF2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
30LFIGMVSKKCNENDImethylation[1]
79AMAQNAIKAMHQSQTubiquitination[2, 3, 4]
103VKFADTQKDKEQRRLubiquitination[3]
105FADTQKDKEQRRLQQubiquitination[3]
353SAKVFIDKQTNLSKCacetylation[5]
353SAKVFIDKQTNLSKCubiquitination[3, 4, 6, 7]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [6] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [7] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 403 AA 
Protein Sequence
MHHPIQMKPA DSEKSNAVED RKLFIGMVSK KCNENDIRVM FSPFGQIEEC RILRGPDGLS 60
RGCAFVTFST RAMAQNAIKA MHQSQTMEGC SSPIVVKFAD TQKDKEQRRL QQQLAQQMQQ 120
LNTATWGNLT GLGGLTPQYL ALLQQATSSS NLGAFSGIQQ MAGMNALQLQ NLATLAAAAA 180
AAQTSATSTN ANPLSTTSSA LGALTSPVAA STPNSTAGAA MNSLTSLGTL QGLAGATVGL 240
NNINALAVAQ MLSGMAALNG GLGATGLTNG TAGTMDALTQ AYSGIQQYAA AALPTLYSQS 300
LLQQQSAAGS QKEGPEGANL FIYHLPQEFG DQDILQMFMP FGNVISAKVF IDKQTNLSKC 360
FGFVSYDNPV SAQAAIQAMN GFQIGMKRLK VQLKRSKNDS KPY 403 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:Compara.
 GO:0006376; P:mRNA splice site selection; IEA:Compara. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS