| Tag | Content |
|---|
| CPLM ID | CPLM-010799 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transcription factor STP1 |
Protein Synonyms/Alias | |
Gene Name | STP1 |
Gene Synonyms/Alias | BAP1; SSY2; YDR463W; D8035.7 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 107 | LSPENRIKSEVNAKS | ubiquitination | [1] | | 113 | IKSEVNAKSLLGSRP | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Transcription factor involved in the regulation of gene expression in response to extracellular amino acid levels. Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS (SSY1-PTR3-SSY5) amino acid sensor system, becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor- regulated genes, including the amino-acid permeases AGP1, BAP2, BAP3 and GNP1. Binding to promoters is facilitated by DAL81. Involved in the repression of genes subject to nitrogen catabolite repression and genes involved in stress response. Negatively regulated by inner nuclear membrane proteins ASI1, ASI2 and ASI3, which prevent unprocessed precursor forms that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes. May be involved in pre-tRNA splicing. |
Sequence Annotation | ZN_FING 160 182 C2H2-type 1.
ZN_FING 188 223 C2H2-type 2; atypical.
ZN_FING 240 265 C2H2-type 3; atypical.
REGION 16 35 I.
REGION 65 97 II. |
Keyword | Cell membrane; Complete proteome; DNA-binding; Membrane; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; tRNA processing; Zinc; Zinc-finger; Zymogen. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 519 AA |
Protein Sequence | MPSTTLLFPQ KHIRAIPGKI YAFFRELVSG VIISKPDLSH HYSCENATKE EGKDAADEEK 60
TTTSLFPESN NIDRSLNGGC SVIPCSMDVS DLNTPISITL SPENRIKSEV NAKSLLGSRP 120
EQDTGAPIKM STGVTSSPLS PSGSTPEHST KVLNNGEEEF ICHYCDATFR IRGYLTRHIK 180
KHAIEKAYHC PFFNSATPPD LRCHNSGGFS RRDTYKTHLK ARHVLYPKGV KPQDRNKSSG 240
HCAQCGEYFS TIENFVENHI ESGDCKALPQ GYTKKNEKRS GKLRKIKTSN GHSRFISTSQ 300
SVVEPKVLFN KDAVEAMTIV ANNSSGNDII SKYGNNKLML NSENFKVDIP KRKRKYIKKK 360
QQQVSGSTVT TPEVATQNNQ EVAPDEISSA TIFSPFDTHL LEPVPSSSSE SSAEVMFHGK 420
QMKNFLIDIN SFTNQQQQAQ DNPSFLPLDI EQSSYDLSED AMSYPIISTQ SNRDCTQYDN 480
TKISQILQSQ LNPEYLSENH MRETQQYLNF YNDNFGSQF 519 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:SGD. GO:0005634; C:nucleus; IDA:SGD. GO:0005886; C:plasma membrane; IDA:SGD. GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IDA:SGD. GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:SGD. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |