CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010411
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Acid-sensing ion channel 1 
Protein Synonyms/Alias
 ASIC1; Amiloride-sensitive cation channel 2, neuronal; Brain sodium channel 2; BNaC2 
Gene Name
 ASIC1 
Gene Synonyms/Alias
 ACCN2; BNAC2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
133DTQMADEKQLEILQDubiquitination[1]
492ALSLDDVKRHNPCESubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
 Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear (By similarity). 
Sequence Annotation
 MOD_RES 479 479 Phosphoserine; by PKA.
 CARBOHYD 368 368 N-linked (GlcNAc...) (Potential).
 CARBOHYD 395 395 N-linked (GlcNAc...) (Potential).
 DISULFID 93 194 By similarity.
 DISULFID 172 179 By similarity.
 DISULFID 290 367 By similarity.
 DISULFID 310 363 By similarity.
 DISULFID 314 361 By similarity.
 DISULFID 323 345 By similarity.
 DISULFID 325 337 By similarity.  
Keyword
 Alternative splicing; Calcium; Calcium transport; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Ion channel; Ion transport; Membrane; Phosphoprotein; Reference proteome; Sodium; Sodium channel; Sodium transport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 528 AA 
Protein Sequence
MELKAEEEEV GGVQPVSIQA FASSSTLHGL AHIFSYERLS LKRALWALCF LGSLAVLLCV 60
CTERVQYYFH YHHVTKLDEV AASQLTFPAV TLCNLNEFRF SQVSKNDLYH AGELLALLNN 120
RYEIPDTQMA DEKQLEILQD KANFRSFKPK PFNMREFYDR AGHDIRDMLL SCHFRGEVCS 180
AEDFKVVFTR YGKCYTFNSG RDGRPRLKTM KGGTGNGLEI MLDIQQDEYL PVWGETDETS 240
FEAGIKVQIH SQDEPPFIDQ LGFGVAPGFQ TFVACQEQRL IYLPPPWGTC KAVTMDSDLD 300
FFDSYSITAC RIDCETRYLV ENCNCRMVHM PGDAPYCTPE QYKECADPAL DFLVEKDQEY 360
CVCEMPCNLT RYGKELSMVK IPSKASAKYL AKKFNKSEQY IGENILVLDI FFEVLNYETI 420
EQKKAYEIAG LLGDIGGQMG LFIGASILTV LELFDYAYEV IKHKLCRRGK CQKEAKRSSA 480
DKGVALSLDD VKRHNPCESL RGHPAGMTYA ANILPHHPAR GTFEDFTC 528 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0045202; C:synapse; IEA:Compara.
 GO:0015280; F:ligand-gated sodium channel activity; NAS:UniProtKB.
 GO:0008306; P:associative learning; IEA:Compara.
 GO:0070588; P:calcium ion transmembrane transport; IEA:Compara.
 GO:0007613; P:memory; IEA:Compara.
 GO:0046929; P:negative regulation of neurotransmitter secretion; IEA:Compara.
 GO:0042391; P:regulation of membrane potential; IEA:Compara.
 GO:0001101; P:response to acid; IEA:Compara.
 GO:0009268; P:response to pH; TAS:ProtInc.
 GO:0007165; P:signal transduction; TAS:ProtInc. 
Interpro
 IPR004724; EnaC.
 IPR001873; Na+channel_ASC.
 IPR020903; Na+channel_ASC_CS. 
Pfam
 PF00858; ASC 
SMART
  
PROSITE
 PS01206; ASC 
PRINTS
 PR01078; AMINACHANNEL.