UniProt Accession

 SODC_YEAST; P00445; D6VWS3; Q68HB2 

Genbank Protein ID

 J03279; AY690619; Z49604; AY558073; BK006943 

Genbank Nucleotide ID

 AAA34543.1; AAT99430.1; CAA89634.1; AAS56399.1; DAA08889.1 

Protein Name

 Superoxide dismutase [Cu-Zn] 

Protein Synonyms/Alias

  

Gene Name

 SOD1 

Gene Synonyms/Alias

 YJR104C; J1968 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
19	AGVSGVVKFEQASES	sumoylation	[1]
69	GPHFNPFKKTHGAPT	sumoylation	[1]
89	VGDMGNVKTDENGVA	acetylation	[2]
97	TDENGVAKGSFKDSL	acetylation	[2]
101	GVAKGSFKDSLIKLI	acetylation	[2]
101	GVAKGSFKDSLIKLI	ubiquitination	[3]
106	SFKDSLIKLIGPTSV	acetylation	[2]
129	AGQDDLGKGDTEESL	acetylation	[2]
129	AGQDDLGKGDTEESL	ubiquitination	[3]
137	GDTEESLKTGNAGPR	acetylation	[2]
137	GDTEESLKTGNAGPR	ubiquitination	[3, 4]

Reference

 [1] Identification of sumoylated proteins by systematic immunoprecipitation of the budding yeast proteome.
 Wykoff DD, O'Shea EK.
 Mol Cell Proteomics. 2005 Jan;4(1):73-83. [PMID: 15596868]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [3] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [4] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 

Functional Description

 Destroys radicals which are normally produced within the cells and which are toxic to biological systems. 

Sequence Annotation

 METAL 43 43 Zinc 2; shared with CCS1; in apo form.
 METAL 47 47 Copper; catalytic.
 METAL 49 49 Copper; catalytic.
 METAL 64 64 Copper; catalytic.
 METAL 64 64 Zinc 1; structural.
 METAL 72 72 Zinc 1; structural.
 METAL 81 81 Zinc 1; structural.
 METAL 84 84 Zinc 1; structural.
 METAL 121 121 Copper; catalytic.
 BINDING 144 144 Substrate (Probable).
 MOD_RES 26 26 Phosphoserine.
 MOD_RES 39 39 Phosphoserine.
 MOD_RES 99 99 Phosphoserine.
 MOD_RES 117 117 Phosphoserine.
 MOD_RES 132 132 Phosphothreonine.
 MOD_RES 138 138 Phosphothreonine.
 DISULFID 58 147 Alternate; alternate.
 DISULFID 58 58 Interchain (with C-229 in CCS1);
 CROSSLNK 19 19 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 70 70 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Antioxidant; Complete proteome; Copper; Cytoplasm; Direct protein sequencing; Disulfide bond; Isopeptide bond; Metal-binding; Mitochondrion; Oxidoreductase; Phosphoprotein; Reference proteome; Ubl conjugation; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 154 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:SGD.
 GO:0005758; C:mitochondrial intermembrane space; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0005507; F:copper ion binding; IBA:RefGenome.
 GO:0004784; F:superoxide dismutase activity; IDA:SGD.
 GO:0008270; F:zinc ion binding; IBA:RefGenome.
 GO:0001320; P:age-dependent response to reactive oxygen species involved in chronological cell aging; IMP:SGD.
 GO:0006878; P:cellular copper ion homeostasis; IGI:SGD.
 GO:0006882; P:cellular zinc ion homeostasis; IMP:SGD.
 GO:0031505; P:fungal-type cell wall organization; IMP:SGD.
 GO:1901856; P:negative regulation of cellular respiration; IMP:SGD.
 GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IMP:SGD.
 GO:0050821; P:protein stabilization; IMP:SGD.
 GO:0019430; P:removal of superoxide radicals; IBA:RefGenome. 

Interpro

 IPR024134; SOD_Cu/Zn_/chaperones.
 IPR018152; SOD_Cu/Zn_BS.
 IPR001424; SOD_Cu_Zn_dom. 

Pfam

 PF00080; Sod_Cu 

SMART

  

PROSITE

 PS00087; SOD_CU_ZN_1
 PS00332; SOD_CU_ZN_2 

PRINTS

 PR00068; CUZNDISMTASE.