UniProt Accession

 CALR3_HUMAN; Q96L12; D9N574; Q96LN3 

Genbank Protein ID

 AB576176; AK058084; AC008764; CH471106; BC014595 

Genbank Nucleotide ID

 BAJ14705.1; BAB71655.1; EAW84546.1; AAH14595.1 

Protein Name

 Calreticulin-3 

Protein Synonyms/Alias

 Calreticulin-2; Calsperin 

Gene Name

 CALR3 

Gene Synonyms/Alias

 CRT2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
230	NKAQDWEKHFLDAST	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility (By similarity). CALR3 capacity for calcium- binding may be absent or much lower than that of CALR. 

Sequence Annotation

 REPEAT 191 202 1-1.
 REPEAT 208 219 1-2.
 REPEAT 221 230 1-3.
 REPEAT 234 245 1-4.
 REPEAT 249 259 2-1.
 REPEAT 263 271 2-2.
 REPEAT 273 283 2-3.
 REGION 20 197 N-domain.
 REGION 191 245 4 X approximate repeats.
 REGION 198 294 P-domain.
 REGION 249 283 3 X approximate repeats.
 REGION 295 384 C-domain.
 MOTIF 381 384 Prevents secretion from ER (Potential).
 BINDING 109 109 Carbohydrate (By similarity).
 BINDING 111 111 Carbohydrate (By similarity).
 BINDING 128 128 Carbohydrate (By similarity).
 BINDING 135 135 Carbohydrate (By similarity).
 BINDING 303 303 Carbohydrate (By similarity).
 CARBOHYD 42 42 N-linked (GlcNAc...) (Potential).
 CARBOHYD 201 201 N-linked (GlcNAc...) (Potential).
 DISULFID 105 137 By similarity.  

Keyword

 Cardiomyopathy; Chaperone; Complete proteome; Differentiation; Disease mutation; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Lectin; Metal-binding; Polymorphism; Reference proteome; Repeat; Signal; Spermatogenesis; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 384 AA 

Protein Sequence

Gene Ontology

 GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0006457; P:protein folding; IEA:InterPro.
 GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW. 

Interpro

 IPR001580; Calret/calnex.
 IPR018124; Calret/calnex_CS.
 IPR009169; Calreticulin.
 IPR009033; Calreticulin/calnexin_P_dom.
 IPR008985; ConA-like_lec_gl_sf.
 IPR013320; ConA-like_subgrp. 

Pfam

 PF00262; Calreticulin 

SMART

  

PROSITE

 PS00803; CALRETICULIN_1
 PS00804; CALRETICULIN_2
 PS00014; ER_TARGET 

PRINTS

 PR00626; CALRETICULIN.