CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007639
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Multidrug resistance protein 1 
Protein Synonyms/Alias
 ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD243 
Gene Name
 Abcb1 
Gene Synonyms/Alias
 Mdr1; Mdr1b; Pgy1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
518FIMKLPHKFDTLVGEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. 
Sequence Annotation
 DOMAIN 49 356 ABC transmembrane type-1 1.
 DOMAIN 391 627 ABC transporter 1.
 DOMAIN 709 1000 ABC transmembrane type-1 2.
 DOMAIN 1035 1272 ABC transporter 2.
 NP_BIND 426 433 ATP 1 (Potential).
 NP_BIND 1070 1077 ATP 2 (Potential).
 MOD_RES 641 641 Phosphotyrosine (By similarity).
 MOD_RES 659 659 Phosphoserine (By similarity).
 CARBOHYD 91 91 N-linked (GlcNAc...) (Potential).
 CARBOHYD 96 96 N-linked (GlcNAc...) (Potential).  
Keyword
 ATP-binding; Cell membrane; Complete proteome; Glycoprotein; Hydrolase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1277 AA 
Protein Sequence
MEFEEGLNGR ADKNFSKMGK KSKKEKEKKP AVGIFGMFRY ADWLDKLCMA LGTLAAIIHG 60
TLLPLLMLVF GYMTDSFTPS RDPHSDRAIT NQSEINSTHT VSDTSLEEDM AMYAYYYTGI 120
GAGVLIVAYI QVSLWCLAAG RQIHKIRQKF FHAIMNQEIG WFDVNDAGEL NTRLTDDVSK 180
INDGIGDKLG MFFQSITTFS AGFIIGFISG WKLTLVILAV SPLIGLSSAM WAKVLTSFTN 240
KELQAYAKAG AVAEEVLAAI RTVIAFGGQK KELERYNKNL EEAKRVGIKK AITANISIGI 300
AYLLVYASYA LAFWYGTSLV LSNEYSIGQV LTVFFSILLG TFSIGHLAPN IEAFANARGA 360
AYEIFKIIDN EPSIDSFSTK GHKPDSIMGN LEFKNVYFNY PSRSEVKILK GLNLKVKSGQ 420
TVALVGNSGC GKSTTVQLLQ RLYDPIEGEV SIDGQDIRTI NVRYLREIIG VVSQEPVLFA 480
TTIAENIRYG RENVTMDEIE KAVKEANAYD FIMKLPHKFD TLVGERGAQL SGGQKQRIAI 540
ARALVRNPKI LLLDEATSAL DTESEAVVQA ALDKAREGRT TIVIAHRLST VRNADVIAGF 600
DGGVIVEQGN HEELMKEKGI YFKLVMTQTR GNEIEPGNNA YESQSDTGAS ELTSEESKSP 660
LIRRSIRRSI HRRQDQERRL SSKEDVDEDV PMVSFWQILK LNISEWPYLV VGVLCAVING 720
CIQPVFAIVF SKIVGVFSRD DDHETKQRNC NLFSLLFLVM GMISFVTYFF QGFTFGKAGE 780
ILTKRLRYMV FKSMLRQDIS WFDDHKNTTG SLTTRLASDA SNVKGAMGSR LAVVTQNVAN 840
LGTGIILSLV LVYGWQLTLL LVVIIPLIVL GGIIEMKLLS GQALKDKKEL EISGKIATEA 900
IENFRTVVSL TREQKFETMY AQSLQIPYRN ALKKAHVFGI TFAFTQAMIY FSYAACFRFG 960
AYLVARELMT FENVMLVFSA VVFGAMAAGN TSSFAPDYAK AKVSASHIIG IIEKIPEIDS 1020
YSTEGLKPNW LEGNVKFNGV KFNYPTRPNI PVLQGLSFEV KKGQTLRLVG SSGCGKSTVV 1080
QLLERFYNPM AGTVFLDGKE IKQLNVQCVR ALGIVSQEPI LFDCSIAENI AYGDNSRVVS 1140
HEEIVRAARE ANIHQFIDSL PEKYNTRVGD KGTQLSGGQK QRIAIARALV RQPHILLLDE 1200
ATSALDTESE KVVQEALDKA REGRTCVVIA HRLSTIQNAD LIVVIQNGQV KEHGTHQQLL 1260
AQKGIYFSMV QAGAKRS 1277 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IDA:RGD.
 GO:0000139; C:Golgi membrane; IDA:RGD.
 GO:0016021; C:integral to membrane; IBA:RefGenome.
 GO:0046581; C:intercellular canaliculus; IBA:RefGenome.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IBA:RefGenome.
 GO:0015238; F:drug transmembrane transporter activity; IMP:RGD.
 GO:0008559; F:xenobiotic-transporting ATPase activity; IEA:EC.
 GO:0071356; P:cellular response to tumor necrosis factor; IEP:RGD.
 GO:0014045; P:establishment of endothelial blood-brain barrier; IMP:RGD.
 GO:0007595; P:lactation; IEP:RGD.
 GO:0046685; P:response to arsenic-containing substance; IEP:RGD.
 GO:0001666; P:response to hypoxia; IEP:RGD.
 GO:0010212; P:response to ionizing radiation; IEP:RGD.
 GO:0014070; P:response to organic cyclic compound; IEP:RGD. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR017940; ABC_transporter_type1.
 IPR001140; ABC_transptr_TM_dom.
 IPR011527; ABC_transptrTM_dom_typ1.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00664; ABC_membrane
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS50929; ABC_TM1F
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS