CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038362
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Rap guanine nucleotide exchange factor 3 
Protein Synonyms/Alias
  
Gene Name
 Rapgef3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
347QDFNRIIKDVEAKTMubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Guanine-nucleotide releasing factor; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 909 AA 
Protein Sequence
MKVSWPGENH WQVGPAVVES PAVGAPQVGG LPDVVPEGTL LNMVLKRMHR PRCCSYQLVF 60
EHRRPSCIQG LRWTPLTNSE DSLDFRVSLE QATTEHVHKA GKLLHRHLLA TYPTLIRDRK 120
YHLRLYRHCC SGRELVDGIL ALGLGVHSRS QAVGICQVLL DEGALCHVKH DWTFQDRDAQ 180
FYRFPGPEPE PTGTQDVEEE LVEAMALLSQ RGPDALLTVA LRKPPGQRTD EELDLIFEEL 240
LHIKAVAHLS NSVKRELAAV LLFEPHSKAG TVLFSQGDKG TSWYIIWKGS VNVVTHGKGL 300
VTTLHEGDDF GQLALVNDAP RAATIILREN NCHFLRVDKQ DFNRIIKDVE AKTMRLEEHG 360
KVVLVLERTS QGAGPSRPPT PGRNRYTVMS GTPEKILELL LEAMRPDSSA HDPTETFLSD 420
FLLTHSVFMP STQLFTALLH HFHVEPADPA GGSEQEHSTY ICNKRQQILR LVGRWVALYS 480
PMLHSDPVAT SFLQKLSDLV SRDARLSNLL REQYPERRRH HRLENGCGNV SPQTKARNAP 540
VWLPNQEEPL PSSAGAIRVG DKVPYDICRP DHSVLTLHLP VTASVREVMA ALAHEDHWTK 600
GQVLVKVNSA GDVVGLQPDA RGVATSLGLN ERLFVVDPQE VHELTPHPEQ LGPTLGSSEM 660
LDLVSAKDLA GQLTDHDWNL FNRIHQVELI HYVLGPQHLR DVTTANLERF MRRFNELQYW 720
VATELCLCPV PGSRAQLLRK FIKLAAHLKE QKNLNSFFAV MFGLSNSAIS RLAHTWEDPS 780
WNHRVYRLAL TKLSPPVIPF MPLLLKDVTF IHEGNHTLVE NLINFEKMRM MARAVRMLHH 840
CRSHSTAPLS PLRSRVSHIH EDSQGSRIST CSEQSLSTRS PASTWAYVQQ LKVIDNQREL 900
SRLSRELEP 909 
Gene Ontology
 GO:0005952; C:cAMP-dependent protein kinase complex; IEA:InterPro.
 GO:0008603; F:cAMP-dependent protein kinase regulator activity; IEA:InterPro.
 GO:0005085; F:guanyl-nucleotide exchange factor activity; IDA:MGI.
 GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR002373; cAMP/cGMP_kin.
 IPR018490; cNMP-bd-like.
 IPR000595; cNMP-bd_dom.
 IPR000591; DEP_dom.
 IPR000651; Ras-like_Gua-exchang_fac_N.
 IPR019804; Ras_G-nucl-exch_fac_CS.
 IPR008937; Ras_GEF.
 IPR023578; Ras_GEF_dom.
 IPR001895; RasGRF_CDC25.
 IPR014710; RmlC-like_jellyroll.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00027; cNMP_binding
 PF00610; DEP
 PF00617; RasGEF
 PF00618; RasGEF_N 
SMART
 SM00100; cNMP
 SM00049; DEP
 SM00147; RasGEF
 SM00229; RasGEFN 
PROSITE
 PS50042; CNMP_BINDING_3
 PS50186; DEP
 PS00720; RASGEF
 PS50009; RASGEF_CAT
 PS50212; RASGEF_NTER 
PRINTS
 PR00103; CAMPKINASE.