UniProt Accession

 CAP1_MOUSE; P40124; Q8BPT7 

Genbank Protein ID

 L12367; AK053351; AL606906; BX545849; BX545849; AL606906; BC005446; BC005472 

Genbank Nucleotide ID

 AAC37610.1; BAC35357.1; CAM13994.1; CAM13994.1; CAM18197.1; CAM18197.1; AAH05446.1; AAH05472.1 

Protein Name

 Adenylyl cyclase-associated protein 1 

Protein Synonyms/Alias

 CAP 1 

Gene Name

 Cap1 

Gene Synonyms/Alias

 Cap 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
62	AEYLKMSKEIGGDVQ	ubiquitination	[1]
154	AKPGPFVKEMNDAAM	acetylation	[2]
177	EYRDVDKKHVDWVRA	acetylation	[2]
208	TTGLAWSKTGPVAKE	acetylation	[2]
286	THKNPALKAQSGPVR	ubiquitination	[1]
326	ALLELEGKKWRVENQ	acetylation	[3]
347	VIDDTELKQVAYIYK	ubiquitination	[1]
411	VPTISINKTDGCHAY	acetylation	[2, 4]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity (By similarity). 

Sequence Annotation

 DOMAIN 312 452 C-CAP/cofactor C-like.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 34 34 Phosphoserine (By similarity).
 MOD_RES 80 80 N6-acetyllysine (By similarity).
 MOD_RES 289 289 Phosphoserine (By similarity).
 MOD_RES 294 294 Phosphoserine (By similarity).
 MOD_RES 300 300 Phosphoserine (By similarity).
 MOD_RES 306 306 Phosphothreonine (By similarity).
 MOD_RES 307 307 Phosphoserine (By similarity).
 MOD_RES 309 309 Phosphoserine.  

Keyword

 Acetylation; Actin-binding; Cell membrane; Complete proteome; Direct protein sequencing; Membrane; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 474 AA 

Protein Sequence

Gene Ontology

 GO:0030864; C:cortical actin cytoskeleton; IDA:MGI.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005576; C:extracellular region; TAS:Reactome.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0030036; P:actin cytoskeleton organization; IMP:MGI.
 GO:0001667; P:ameboidal cell migration; IMP:MGI.
 GO:0000902; P:cell morphogenesis; IGI:MGI.
 GO:0006898; P:receptor-mediated endocytosis; IMP:MGI. 

Interpro

 IPR001837; Adenylate_cyclase-assoc_CAP.
 IPR013912; Adenylate_cyclase-assoc_CAP_C.
 IPR013992; Adenylate_cyclase-assoc_CAP_N.
 IPR017901; C-CAP_CF_C-like.
 IPR016098; CAP/MinC_C.
 IPR018106; CAP_CS.
 IPR006599; CARP_motif. 

Pfam

 PF08603; CAP_C
 PF01213; CAP_N 

SMART

 SM00673; CARP 

PROSITE

 PS51329; C_CAP_COFACTOR_C
 PS01088; CAP_1
 PS01089; CAP_2 

PRINTS