UniProt Accession

 RAD51_HUMAN; Q06609; B0FXP0; B2R8T6; Q6FHX9; Q6ZNA8; Q9BV60 

Genbank Protein ID

 D13804; D14134; AF165094; AF165088; AF165089; AF165090; AF165091; AF165092; AF165093; AF233744; AF233740; AF233741; AF233742; AF236021; AF233743; EU362635; AY196785; AK131299; AK291969; AK313503; CR536559; AC012476; AC022405; CH471125; CH471125; CH471125; BC001459 

Genbank Nucleotide ID

 BAA02962.1; BAA03189.1; AAD49705.1; AAD49705.1; AAD49705.1; AAD49705.1; AAD49705.1; AAD49705.1; AAD49705.1; AAF69145.1; AAF69145.1; AAF69145.1; AAF69145.1; AAF69145.1; AAF69145.1; ABY59731.1; AAN87149.1; BAD18467.1; BAF84658.1; BAG36283.1; CAG38796.1; EAW92434.1; EAW92432.1; EAW92435.1; AAH01459.1 

Protein Name

 DNA repair protein RAD51 homolog 1 

Protein Synonyms/Alias

 HsRAD51; hRAD51; RAD51 homolog A 

Gene Name

 RAD51 

Gene Synonyms/Alias

 RAD51A; RECA 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
58	AVAYAPKKELINIKG	ubiquitination	[1]
64	KKELINIKGISEAKA	ubiquitination	[1]
107	IQITTGSKELDKLLQ	ubiquitination	[2]
156	DRGGGEGKAMYIDTE	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. 

Sequence Annotation

 DOMAIN 48 77 HhH.
 NP_BIND 127 134 ATP (By similarity).
 REGION 184 257 Interaction with PALB2.
 MOD_RES 54 54 Phosphotyrosine; by ABL1.
 MOD_RES 309 309 Phosphothreonine; by CHEK1.  

Keyword

 3D-structure; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Disease mutation; DNA damage; DNA recombination; DNA repair; DNA-binding; Mitochondrion; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 339 AA 

Protein Sequence

Gene Ontology

 GO:0000794; C:condensed nuclear chromosome; ISS:UniProtKB.
 GO:0000800; C:lateral element; IEA:Compara.
 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
 GO:0016605; C:PML body; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IDA:MGI.
 GO:0003684; F:damaged DNA binding; IEA:InterPro.
 GO:0003690; F:double-stranded DNA binding; IDA:UniProtKB.
 GO:0003697; F:single-stranded DNA binding; IDA:UniProtKB.
 GO:0043142; F:single-stranded DNA-dependent ATPase activity; IDA:UniProtKB.
 GO:0000730; P:DNA recombinase assembly; TAS:Reactome.
 GO:0006268; P:DNA unwinding involved in replication; IDA:UniProtKB.
 GO:0006312; P:mitotic recombination; TAS:ProtInc.
 GO:0051106; P:positive regulation of DNA ligation; IDA:UniProtKB.
 GO:0051260; P:protein homooligomerization; IPI:UniProtKB.
 GO:0007131; P:reciprocal meiotic recombination; TAS:ProtInc. 

Interpro

 IPR003593; AAA+_ATPase.
 IPR011941; DNA_recomb/repair_Rad51.
 IPR013632; DNA_recomb/repair_Rad51_C.
 IPR016467; DNA_recomb/repair_RecA-like.
 IPR020588; DNA_recomb_RecA/RadB_ATP-bd.
 IPR010995; DNA_repair_Rad51/TF_NusA_a-hlx.
 IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
 IPR027417; P-loop_NTPase.
 IPR020587; RecA_monomer-monomer_interface. 

Pfam

 PF08423; Rad51 

SMART

 SM00382; AAA
 SM00278; HhH1 

PROSITE

 PS50162; RECA_2
 PS50163; RECA_3 

PRINTS