CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014110
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 
Protein Synonyms/Alias
 PGC-1-related coactivator; PRC 
Gene Name
 PPRC1 
Gene Synonyms/Alias
 KIAA0595 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
166REGSSLHKLLTLSRTubiquitination[1]
1549RRVVFIGKIPGRMTRubiquitination[1]
1603AAIESGHKLRQADEQubiquitination[1]
1643DFDPAPVKSKFDSLDubiquitination[2]
1645DPAPVKSKFDSLDFDubiquitination[1, 2]
1656LDFDTLLKQAQKNLRubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. 
Sequence Annotation
 DOMAIN 1543 1619 RRM.
 REGION 433 467 Necessary for interaction with CREB1 and
 REGION 1379 1450 Necessary for interaction with CREB1 and
 MOD_RES 536 536 Phosphoserine.
 MOD_RES 1411 1411 Phosphoserine.
 MOD_RES 1413 1413 Phosphoserine.  
Keyword
 Activator; Alternative splicing; Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; RNA-binding; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1664 AA 
Protein Sequence
MAARRGRRDG VAPPPSGGPG PDPGGGARGS GWGSRSQAPY GTLGAVSGGE QVLLHEEAGD 60
SGFVSLSRLG PSLRDKDLEM EELMLQDETL LGTMQSYMDA SLISLIEDFG SLGESRLSLE 120
DQNEVSLLTA LTEILDNADS ENLSPFDSIP DSELLVSPRE GSSLHKLLTL SRTPPERDLI 180
TPVDPLGPST GSSRGSGVEM SLPDPSWDFS PPSFLETSSP KLPSWRPPRS RPRWGQSPPP 240
QQRSDGEEEE EVASFSGQIL AGELDNCVSS IPDFPMHLAC PEEEDKATAA EMAVPAAGDE 300
SISSLSELVR AMHPYCLPNL THLASLEDEL QEQPDDLTLP EGCVVLEIVG QAATAGDDLE 360
IPVVVRQVSP GPRPVLLDDS LETSSALQLL MPTLESETEA AVPKVTLCSE KEGLSLNSEE 420
KLDSACLLKP REVVEPVVPK EPQNPPANAA PGSQRARKGR KKKSKEQPAA CVEGYARRLR 480
SSSRGQSTVG TEVTSQVDNL QKQPQEELQK ESGPLQGKGK PRAWARAWAA ALENSSPKNL 540
ERSAGQSSPA KEGPLDLYPK LADTIQTNPI PTHLSLVDSA QASPMPVDSV EADPTAVGPV 600
LAGPVPVDPG LVDLASTSSE LVEPLPAEPV LINPVLADSA AVDPAVVPIS DNLPPVDAVP 660
SGPAPVDLAL VDPVPNDLTP VDPVLVKSRP TDPRRGAVSS ALGGSAPQLL VESESLDPPK 720
TIIPEVKEVV DSLKIESGTS ATTHEARPRP LSLSEYRRRR QQRQAETEER SPQPPTGKWP 780
SLPETPTGLA DIPCLVIPPA PAKKTALQRS PETPLEICLV PVGPSPASPS PEPPVSKPVA 840
SSPTEQVPSQ EMPLLARPSP PVQSVSPAVP TPPSMSAALP FPAGGLGMPP SLPPPPLQPP 900
SLPLSMGPVL PDPFTHYAPL PSWPCYPHVS PSGYPCLPPP PTVPLVSGTP GAYAVPPTCS 960
VPWAPPPAPV SPYSSTCTYG PLGWGPGPQH APFWSTVPPP PLPPASIGRA VPQPKMESRG 1020
TPAGPPENVL PLSMAPPLSL GLPGHGAPQT EPTKVEVKPV PASPHPKHKV SALVQSPQMK 1080
ALACVSAEGV TVEEPASERL KPETQETRPR EKPPLPATKA VPTPRQSTVP KLPAVHPARL 1140
RKLSFLPTPR TQGSEDVVQA FISEIGIEAS DLSSLLEQFE KSEAKKECPP PAPADSLAVG 1200
NSGGVDIPQE KRPLDRLQAP ELANVAGLTP PATPPHQLWK PLAAVSLLAK AKSPKSTAQE 1260
GTLKPEGVTE AKHPAAVRLQ EGVHGPSRVH VGSGDHDYCV RSRTPPKKMP ALVIPEVGSR 1320
WNVKRHQDIT IKPVLSLGPA APPPPCIAAS REPLDHRTSS EQADPSAPCL APSSLLSPEA 1380
SPCRNDMNTR TPPEPSAKQR SMRCYRKACR SASPSSQGWQ GRRGRNSRSV SSGSNRTSEA 1440
SSSSSSSSSS SRSRSRSLSP PHKRWRRSSC SSSGRSRRCS SSSSSSSSSS SSSSSSSSSR 1500
SRSRSPSPRR RSDRRRRYSS YRSHDHYQRQ RVLQKERAIE ERRVVFIGKI PGRMTRSELK 1560
QRFSVFGEIE ECTIHFRVQG DNYGFVTYRY AEEAFAAIES GHKLRQADEQ PFDLCFGGRR 1620
QFCKRSYSDL DSNREDFDPA PVKSKFDSLD FDTLLKQAQK NLRR 1664 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS