CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006338
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein SOF1 
Protein Synonyms/Alias
 U3 small nucleolar RNA-associated protein SOF1; U3 snoRNA-associated protein SOF1 
Gene Name
 SOF1 
Gene Synonyms/Alias
 YLL011W; L1339 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
467QIVGTVHKYEDSGRDacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Required for ribosomal RNA processing. 
Sequence Annotation
 REPEAT 65 105 WD 1.
 REPEAT 113 158 WD 2.
 REPEAT 177 214 WD 3.
 REPEAT 217 257 WD 4.
 REPEAT 259 299 WD 5.
 REPEAT 303 342 WD 6.
 REPEAT 346 385 WD 7.  
Keyword
 Complete proteome; Nucleus; Reference proteome; Repeat; Ribonucleoprotein; Ribosome biogenesis; rRNA processing; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 489 AA 
Protein Sequence
MKIKTIKRSA DDYVPVKSTQ ESQMPRNLNP ELHPFERARE YTKALNATKL ERMFAKPFVG 60
QLGYGHRDGV YAIAKNYGSL NKLATGSADG VIKYWNMSTR EEFVSFKAHY GLVTGLCVTQ 120
PRFHDKKPDL KSQNFMLSCS DDKTVKLWSI NVDDYSNKNS SDNDSVTNEE GLIRTFDGES 180
AFQGIDSHRE NSTFATGGAK IHLWDVNRLK PVSDLSWGAD NITSLKFNQN ETDILASTGS 240
DNSIVLYDLR TNSPTQKIVQ TMRTNAICWN PMEAFNFVTA NEDHNAYYYD MRNLSRSLNV 300
FKDHVSAVMD VDFSPTGDEI VTGSYDKSIR IYKTNHGHSR EIYHTKRMQH VFQVKYSMDS 360
KYIISGSDDG NVRLWRSKAW ERSNVKTTRE KNKLEYDEKL KERFRHMPEI KRISRHRHVP 420
QVIKKAQEIK NIELSSIKRR EANERRTRKD MPYISERKKQ IVGTVHKYED SGRDRKRRKE 480
DDKRDTQEK 489 
Gene Ontology
 GO:0030686; C:90S preribosome; IDA:SGD.
 GO:0005730; C:nucleolus; IDA:SGD.
 GO:0032040; C:small-subunit processome; IDA:SGD.
 GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD. 
Interpro
 IPR020472; G-protein_beta_WD-40_rep.
 IPR007287; Sof1.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF04158; Sof1
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00320; GPROTEINBRPT.