UniProt Accession

 ACBP_DROME; P42281; A4V1K8; Q9VS23 

Genbank Protein ID

 U04822; U04823; X75596; AE014296; AE014296; AY070704 

Genbank Nucleotide ID

 AAA21649.1; AAA21650.1; CAA53268.1; AAF50607.1; AAN12074.1; AAL48175.1 

Protein Name

 Acyl-CoA-binding protein homolog 

Protein Synonyms/Alias

 ACBP; Diazepam-binding inhibitor homolog; DBI 

Gene Name

 Dbi 

Gene Synonyms/Alias

 CG8627 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
51	KPGLLDLKGKAKWEA	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters (By similarity). May be involved in energy metabolism in a manner that depends on the substrate used for energy production. Dbi and its metabolites are involved in the regulation of multiple biological processes. 

Sequence Annotation

 DOMAIN 2 86 ACB.
 REGION 29 33 Acyl-CoA binding (By similarity).
 BINDING 14 14 Acyl-CoA (By similarity).
 BINDING 51 51 Acyl-CoA (By similarity).
 BINDING 55 55 Acyl-CoA (By similarity).
 BINDING 74 74 Acyl-CoA (By similarity).  

Keyword

 Complete proteome; Lipid-binding; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 86 AA 

Protein Sequence

Gene Ontology

 GO:0000062; F:fatty-acyl-CoA binding; ISS:FlyBase.
 GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
 GO:0042049; P:cellular acyl-CoA homeostasis; ISS:FlyBase.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 

Interpro

 IPR022408; Acyl-CoA-binding_prot_CS.
 IPR000582; Acyl-CoA-binding_protein.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx. 

Pfam

 PF00887; ACBP 

SMART

  

PROSITE

 PS00880; ACB_1
 PS51228; ACB_2 

PRINTS

 PR00689; ACOABINDINGP.