CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020812
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ELL-associated factor 1 
Protein Synonyms/Alias
  
Gene Name
 Eaf1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
150MPFRAPTKPPAGPKTacetylation[1]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Acts as a transcriptional transactivator of ELL and ELL2 elongation activities (By similarity). 
Sequence Annotation
 REGION 182 262 Necessary for transactivation activity
 MOD_RES 158 158 Phosphoserine.
 MOD_RES 165 165 Phosphoserine.  
Keyword
 Activator; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 268 AA 
Protein Sequence
MNGTANPLLD REEHCLRLGE SFEKRPRASF HTIRYDFKPA SIDTSCEGEL QVGKGDEVTI 60
TLPHIPGSTP PMTVFKGNKR PYQKDCVLII NHDTGEYVLE KLSSSIQVKK TRAEGSSKIQ 120
ARMEQQPARP PQPSQPPPPP PPMPFRAPTK PPAGPKTSPL KDNPSPEPQL DDIKRELRAE 180
VDIIEQMSSS SGSSSSDSES SSGSDDDSSS SAGEDNGPAS PPQPSHQQPY NSRPAVANGT 240
SRPQGSSQLM NTLRNDLQLS ESGSDSDD 268 
Gene Ontology
 GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell.
 GO:0032783; C:ELL-EAF complex; IEA:InterPro.
 GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR027093; EAF_fam.
 IPR019194; Tscrpt_elong_fac_Eaf_N. 
Pfam
 PF09816; EAF 
SMART
  
PROSITE
  
PRINTS