UniProt Accession

 TNNC1_HUMAN; P63316; O14800; P02590; P04463 

Genbank Protein ID

 X07897; M37984; AF020769; BC030244 

Genbank Nucleotide ID

 CAA30736.1; AAA36772.1; AAB91994.1; AAH30244.1 

Protein Name

 Troponin C, slow skeletal and cardiac muscles 

Protein Synonyms/Alias

 TN-C 

Gene Name

 TNNC1 

Gene Synonyms/Alias

 TNNC 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
106	DLFRMFDKNADGYID	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. 

Sequence Annotation

 DOMAIN 16 51 EF-hand 1.
 DOMAIN 52 87 EF-hand 2.
 DOMAIN 92 127 EF-hand 3.
 DOMAIN 128 161 EF-hand 4.
 MOD_RES 1 1 N-acetylmethionine.  

Keyword

 3D-structure; Acetylation; Calcium; Cardiomyopathy; Complete proteome; Direct protein sequencing; Disease mutation; Metal-binding; Muscle protein; Polymorphism; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 161 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005861; C:troponin complex; IDA:UniProtKB.
 GO:0051015; F:actin filament binding; ISS:BHF-UCL.
 GO:0005509; F:calcium ion binding; IDA:BHF-UCL.
 GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL.
 GO:0031013; F:troponin I binding; IDA:BHF-UCL.
 GO:0060048; P:cardiac muscle contraction; IMP:BHF-UCL.
 GO:0030049; P:muscle filament sliding; TAS:Reactome.
 GO:0043462; P:regulation of ATPase activity; ISS:BHF-UCL.
 GO:0032972; P:regulation of muscle filament sliding speed; ISS:BHF-UCL.
 GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IMP:BHF-UCL. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR001125; Recoverin. 

Pfam

 PF13499; EF_hand_5 

SMART

 SM00054; EFh 

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 

PRINTS

 PR00450; RECOVERIN.