UniProt Accession

 B6VGH4_MOUSE; B6VGH4 

Genbank Protein ID

 FJ392393; CH466522 

Genbank Nucleotide ID

 ACJ12937.1; EDL25920.1 

Protein Name

 Cytochrome P450 family 1 subfamily a polypeptide 2 

Protein Synonyms/Alias

 MCG4004 

Gene Name

 Cyp1a2 

Gene Synonyms/Alias

 mCG_4004 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
94	LSGLNTIKQALVRQG	ubiquitination	[1]
105	VRQGDDFKGRPDLYS	ubiquitination	[1]
120	FTLITNGKSMTFNPD	ubiquitination	[1]
144	RLAQDALKSFSIASD	ubiquitination	[1]
166	YLEEHVSKEANHLVS	ubiquitination	[1]
174	EANHLVSKLQKAMAE	ubiquitination	[1]
211	FGKNFPRKSEEMLNI	ubiquitination	[1]
250	YLPNPALKRFKTFND	ubiquitination	[1]
253	NPALKRFKTFNDNFV	ubiquitination	[1]
276	EHYQDFNKNSIQDIT	ubiquitination	[1]
288	DITSALFKHSENYKD	ubiquitination	[1]
294	FKHSENYKDNGGLIP	ubiquitination	[1]
340	TWPNVQRKIHEELDT	ubiquitination	[1]
401	LNGFHIPKERCIYIN	ubiquitination	[1]
417	WQVNHDEKQWKDPFV	ubiquitination	[1]
420	NHDEKQWKDPFVFRP	ubiquitination	[1]
440	NNNSAIDKTQSEKVM	ubiquitination	[1]
445	IDKTQSEKVMLFGLG	ubiquitination	[1]
453	VMLFGLGKRRCIGEI	ubiquitination	[1]
498	PNYGLTMKPGTCEHV	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

  

Keyword

 Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 513 AA 

Protein Sequence

Gene Ontology

 GO:0043231; C:intracellular membrane-bounded organelle; IEA:Compara.
 GO:0034875; F:caffeine oxidase activity; IEA:Compara.
 GO:0032451; F:demethylase activity; IEA:Compara.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:Compara.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IDA:MGI.
 GO:0009820; P:alkaloid metabolic process; IEA:Compara.
 GO:0045333; P:cellular respiration; IMP:MGI.
 GO:0071276; P:cellular response to cadmium ion; IDA:MGI.
 GO:0018894; P:dibenzo-p-dioxin metabolic process; IMP:MGI.
 GO:0017144; P:drug metabolic process; IMP:MGI.
 GO:0042738; P:exogenous drug catabolic process; IEA:Compara.
 GO:0050665; P:hydrogen peroxide biosynthetic process; IMP:MGI.
 GO:0030324; P:lung development; IMP:MGI.
 GO:0032787; P:monocarboxylic acid metabolic process; IEA:Compara.
 GO:0016098; P:monoterpenoid metabolic process; IEA:Compara.
 GO:0071615; P:oxidative deethylation; IEA:Compara.
 GO:0070989; P:oxidative demethylation; IEA:Compara.
 GO:0006778; P:porphyrin-containing compound metabolic process; IMP:MGI.
 GO:0009791; P:post-embryonic development; IMP:MGI.
 GO:0010468; P:regulation of gene expression; IMP:MGI.
 GO:0032355; P:response to estradiol stimulus; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0006950; P:response to stress; IEA:Compara.
 GO:0006706; P:steroid catabolic process; IEA:Compara.
 GO:0009403; P:toxin biosynthetic process; IEA:Compara.
 GO:0009404; P:toxin metabolic process; IMP:MGI. 

Interpro

 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I.
 IPR008066; Cyt_P450_E_grp-I_CYP1. 

Pfam

 PF00067; p450 

SMART

  

PROSITE

 PS00086; CYTOCHROME_P450 

PRINTS

 PR00463; EP450I.
 PR01683; EP450ICYP1A.
 PR00385; P450.