UniProt Accession

 HDEB_ECOLI; P0AET2; P26605; Q2M7H1 

Genbank Protein ID

 D11109; U00039; U00096; AP009048 

Genbank Nucleotide ID

 BAA01884.1; AAB18485.1; AAC76534.2; BAE77785.1 

Protein Name

 Acid stress chaperone HdeB 

Protein Synonyms/Alias

 10K-L protein 

Gene Name

 hdeB 

Gene Synonyms/Alias

 yhhD; yhiC; b3509; JW5669 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
82	TDLTQIPKVIEYCKK	acetylation	[1]
88	PKVIEYCKKNPQKNL	acetylation	[1]
93	YCKKNPQKNLYTFKN	acetylation	[1, 2, 3]
99	QKNLYTFKNQASNDL	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli.
 Zhang J, Sprung R, Pei J, Tan X, Kim S, Zhu H, Liu CF, Grishin NV, Zhao Y.
 Mol Cell Proteomics. 2009 Feb;8(2):215-25. [PMID: 18723842]
 [3] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111] 

Functional Description

 Required for optimal acid stress protection, which is important for survival of enteric bacteria in the acidic environment of the host stomach. Exhibits a chaperone-like activity at acidic pH by preventing the aggregation of many different periplasmic proteins. 

Sequence Annotation

 MOD_RES 93 93 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Chaperone; Complete proteome; Direct protein sequencing; Periplasm; Reference proteome; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 108 AA 

Protein Sequence

Gene Ontology

 GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
 GO:0051082; F:unfolded protein binding; IDA:EcoCyc.
 GO:0009268; P:response to pH; IMP:EcoCyc. 

Interpro

 IPR010486; HNS-dep_expression_A/B. 

Pfam

 PF06411; HdeA 

SMART

  

PROSITE

  

PRINTS