UniProt Accession

 PCC1_YEAST; Q3E833; D6VXF6 

Genbank Protein ID

 Z28320; Z28321; BK006944 

Genbank Nucleotide ID

 DAA09246.1 

Protein Name

 Polarized growth chromatin-associated controller 1 

Protein Synonyms/Alias

  

Gene Name

 PCC1 

Gene Synonyms/Alias

 YKR095W-A 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
39	LSPDPILKPQDFQVD	acetylation	[1]
39	LSPDPILKPQDFQVD	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Component of the EKC/KEOPS complex which promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. 

Sequence Annotation

  

Keyword

 Activator; Chromosome; Complete proteome; Nucleus; Reference proteome; Telomere; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 88 AA 

Protein Sequence

Gene Ontology

 GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
 GO:0000408; C:EKC/KEOPS complex; IDA:SGD.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0031490; F:chromatin DNA binding; IDA:SGD.
 GO:0007329; P:positive regulation of transcription from RNA polymerase II promoter by pheromones; IMP:SGD.
 GO:0070525; P:threonylcarbamoyladenosine metabolic process; IMP:SGD.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR015419; EKC/KEOPS_Pcc1. 

Pfam

 PF09341; Pcc1 

SMART

  

PROSITE

  

PRINTS