CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038138
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Dihydropyrimidinase-related protein 3 
Protein Synonyms/Alias
  
Gene Name
 Dpysl3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
33TDQVPRQKYGGMFCNacetylation[1]
169LIVPGGVKTIEANGKacetylation[2]
169LIVPGGVKTIEANGKubiquitination[3]
536ALKIVSAKNHQSVAEubiquitination[3]
593PFSDYVYKRIKARRKacetylation[1]
600KRIKARRKMADLHAVubiquitination[3]
624FDLTTTPKGGTPAGSubiquitination[3]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 683 AA 
Protein Sequence
MASGRRGWDS SHEDDLPVYL ARPGTTDQVP RQKYGGMFCN VEGAFESKTL DFDALSVGQR 60
GAKTPRSSQG SGRGAGNRPG MEVDARRGPG REESREPAPE SPKPAGVEIR SATGKEVLQN 120
LGPKDKSDRL LIKGGRIVND DQSFYADIYM EDGLIKQIGD NLIVPGGVKT IEANGKMVIP 180
GGIDVHTHFQ MPYKGMTTVD DFFQGTKAAL AGGTTMIIDH VVPEPESSLT EAYEKWREWA 240
DGKSCCDYAL HVDITHWNDS VKQEVQSLSK EKGVNSFMVY MAYKDLYQVS NTELYEIFTC 300
LGELGAIAQV HAENGDIIAQ EQARMLEMGI TGPEGHVLSR PEELEAEAVF RAITVASQTN 360
CPLYVTKVMS KSAADLISQA RKKGNVVFGE PITASLGIDG THYWSKNWAK AAAFVTSPPL 420
SPDPTTPDYI NSLLASGDLQ LSGSAHCTFS TAQKAIGKDN FTAIPEGTNG VEERMSVIWD 480
KAVATGKMDE NQFVAVTSTN AAKIFNLYPR KGRIAVGSDS DLVIWDPDAL KIVSAKNHQS 540
VAEYNIFEGM ELRGAPLVVI CQGKIMLEDG NLHVTQGAGR FIPCSPFSDY VYKRIKARRK 600
MADLHAVPRG MYDGPVFDLT TTPKGGTPAG STRGSPTRPN PPVRNLHQSG FSLSGTQVDE 660
GVRSASKRIV APPGGRSNIT SLS 683 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0016812; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides; IEA:InterPro.
 GO:0007399; P:nervous system development; IDA:MGI.
 GO:0006208; P:pyrimidine nucleobase catabolic process; IEA:InterPro. 
Interpro
 IPR006680; Amidohydro_1.
 IPR011778; Hydantoinase/dihydroPyrase.
 IPR011059; Metal-dep_hydrolase_composite. 
Pfam
 PF01979; Amidohydro_1 
SMART
  
PROSITE
  
PRINTS