CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004414
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 L-serine dehydratase 1 
Protein Synonyms/Alias
 SDH 1; L-serine deaminase 1; L-SD1 
Gene Name
 sdaA 
Gene Synonyms/Alias
 b1814; JW1803 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
36FVDDLVEKGLLDSVTacetylation[1]
402RNAIASVKAINAARMacetylation[1]
423APRVSLDKVIETMYEacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Deaminates also threonine, particularly when it is present in high concentration. 
Sequence Annotation
  
Keyword
 4Fe-4S; Complete proteome; Direct protein sequencing; Gluconeogenesis; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 454 AA 
Protein Sequence
MISLFDMFKV GIGPSSSHTV GPMKAGKQFV DDLVEKGLLD SVTRVAVDVY GSLSLTGKGH 60
HTDIAIIMGL AGNEPATVDI DSIPGFIRDV EERERLLLAQ GRHEVDFPRD NGMRFHNGNL 120
PLHENGMQIH AYNGDEVVYS KTYYSIGGGF IVDEEHFGQD AANEVSVPYP FKSATELLAY 180
CNETGYSLSG LAMQNELALH SKKEIDEYFA HVWQTMQACI DRGMNTEGVL PGPLRVPRRA 240
SALRRMLVSS DKLSNDPMNV IDWVNMFALA VNEENAAGGR VVTAPTNGAC GIVPAVLAYY 300
DHFIESVSPD IYTRYFMAAG AIGALYKMNA SISGAEVGCQ GEVGVACSMA AAGLAELLGG 360
SPEQVCVAAE IGMEHNLGLT CDPVAGQVQV PCIERNAIAS VKAINAARMA LRRTSAPRVS 420
LDKVIETMYE TGKDMNAKYR ETSRGGLAIK VQCD 454 
Gene Ontology
 GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0003941; F:L-serine ammonia-lyase activity; IDA:EcoCyc.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
 GO:0006565; P:L-serine catabolic process; IDA:EcoCyc. 
Interpro
 IPR004644; Fe-S_L-Ser_mono.
 IPR005130; Ser_deHydtase-like_asu.
 IPR005131; Ser_deHydtase_bsu. 
Pfam
 PF03313; SDH_alpha
 PF03315; SDH_beta 
SMART
  
PROSITE
  
PRINTS