CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002245
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Intercellular adhesion molecule 1 
Protein Synonyms/Alias
 ICAM-1; Major group rhinovirus receptor; CD54 
Gene Name
 ICAM1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
359PRAQLLLKATPEDNGubiquitination[1]
524AQKGTPMKPNTQATPubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans- endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus. 
Sequence Annotation
 DOMAIN 41 103 Ig-like C2-type 1.
 DOMAIN 128 193 Ig-like C2-type 2.
 DOMAIN 230 297 Ig-like C2-type 3.
 DOMAIN 325 378 Ig-like C2-type 4.
 DOMAIN 412 464 Ig-like C2-type 5.
 MOTIF 152 154 Cell attachment site; atypical
 MOD_RES 521 521 Phosphothreonine.
 MOD_RES 530 530 Phosphothreonine.
 CARBOHYD 130 130 N-linked (GlcNAc...).
 CARBOHYD 145 145 N-linked (GlcNAc...).
 CARBOHYD 183 183 N-linked (GlcNAc...).
 CARBOHYD 202 202 N-linked (GlcNAc...).
 CARBOHYD 260 260 N-linked (GlcNAc...).
 CARBOHYD 267 267 N-linked (GlcNAc...).
 CARBOHYD 296 296 N-linked (GlcNAc...).
 CARBOHYD 385 385 N-linked (GlcNAc...).
 CARBOHYD 406 406 N-linked (GlcNAc...) (Potential).
 DISULFID 48 92
 DISULFID 52 96
 DISULFID 135 186
 DISULFID 237 290
 DISULFID 332 371
 DISULFID 403 419
 DISULFID 431 457  
Keyword
 3D-structure; Cell adhesion; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Host cell receptor for virus entry; Host-virus interaction; Immunoglobulin domain; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 532 AA 
Protein Sequence
MAPSSPRPAL PALLVLLGAL FPGPGNAQTS VSPSKVILPR GGSVLVTCST SCDQPKLLGI 60
ETPLPKKELL LPGNNRKVYE LSNVQEDSQP MCYSNCPDGQ STAKTFLTVY WTPERVELAP 120
LPSWQPVGKN LTLRCQVEGG APRANLTVVL LRGEKELKRE PAVGEPAEVT TTVLVRRDHH 180
GANFSCRTEL DLRPQGLELF ENTSAPYQLQ TFVLPATPPQ LVSPRVLEVD TQGTVVCSLD 240
GLFPVSEAQV HLALGDQRLN PTVTYGNDSF SAKASVSVTA EDEGTQRLTC AVILGNQSQE 300
TLQTVTIYSF PAPNVILTKP EVSEGTEVTV KCEAHPRAKV TLNGVPAQPL GPRAQLLLKA 360
TPEDNGRSFS CSATLEVAGQ LIHKNQTREL RVLYGPRLDE RDCPGNWTWP ENSQQTPMCQ 420
AWGNPLPELK CLKDGTFPLP IGESVTVTRD LEGTYLCRAR STQGEVTRKV TVNVLSPRYE 480
IVIITVVAAA VIMGTAGLST YLYNRQRKIK KYRLQQAQKG TPMKPNTQAT PP 532 
Gene Ontology
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0005615; C:extracellular space; IDA:BHF-UCL.
 GO:0001772; C:immunological synapse; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
 GO:0051856; P:adhesion to symbiont; IDA:BHF-UCL.
 GO:0033627; P:cell adhesion mediated by integrin; IEA:Compara.
 GO:0007569; P:cell aging; IEA:Compara.
 GO:0071312; P:cellular response to alkaloid; IEA:Compara.
 GO:0071333; P:cellular response to glucose stimulus; IEA:Compara.
 GO:0071456; P:cellular response to hypoxia; IEA:Compara.
 GO:0071347; P:cellular response to interleukin-1; IEA:Compara.
 GO:0071222; P:cellular response to lipopolysaccharide; IEA:Compara.
 GO:0031669; P:cellular response to nutrient levels; IEA:Compara.
 GO:0071356; P:cellular response to tumor necrosis factor; IEA:Compara.
 GO:0007157; P:heterophilic cell-cell adhesion; TAS:BHF-UCL.
 GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.
 GO:0007159; P:leukocyte cell-cell adhesion; IMP:BHF-UCL.
 GO:0050900; P:leukocyte migration; IEP:BHF-UCL.
 GO:0022614; P:membrane to membrane docking; IEP:BHF-UCL.
 GO:0051926; P:negative regulation of calcium ion transport; IEA:Compara.
 GO:0001541; P:ovarian follicle development; IEA:Compara.
 GO:0002693; P:positive regulation of cellular extravasation; IMP:BHF-UCL.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Compara.
 GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Compara.
 GO:0045907; P:positive regulation of vasoconstriction; IEA:Compara.
 GO:0030155; P:regulation of cell adhesion; IEA:Compara.
 GO:0008360; P:regulation of cell shape; IEA:Compara.
 GO:0050776; P:regulation of immune response; TAS:Reactome.
 GO:0001910; P:regulation of leukocyte mediated cytotoxicity; TAS:BHF-UCL.
 GO:0043200; P:response to amino acid stimulus; IEA:Compara.
 GO:0001975; P:response to amphetamine; IEA:Compara.
 GO:0046688; P:response to copper ion; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0034698; P:response to gonadotropin stimulus; IEA:Compara.
 GO:0010212; P:response to ionizing radiation; IEA:Compara.
 GO:0014070; P:response to organic cyclic compound; IEA:Compara.
 GO:0010477; P:response to sulfur dioxide; IEA:Compara.
 GO:0002291; P:T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; IMP:BHF-UCL.
 GO:0002457; P:T cell antigen processing and presentation; IEA:Compara.
 GO:0046813; P:virion attachment, binding of host cell surface receptor; IDA:BHF-UCL. 
Interpro
 IPR003988; ICAM.
 IPR013768; ICAM_N.
 IPR003987; ICAM_VCAM_N.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub. 
Pfam
 PF03921; ICAM_N 
SMART
 SM00409; IG 
PROSITE
 PS50835; IG_LIKE 
PRINTS
 PR01473; ICAM.
 PR01472; ICAMVCAM1.