CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039034
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Heat shock 70 kDa protein 4 
Protein Synonyms/Alias
  
Gene Name
 Hspa4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
253EEFGKKYKLDIKSKVacetylation[1]
257KKYKLDIKSKVRALLacetylation[1]
272RLSQECEKLKKLMSAacetylation[1]
356AVKEKISKFFGKELSacetylation[1]
430NHAAPFSKVLTFYRKacetylation[1]
631YVYEMRDKLSGEYEKacetylation[1]
668EDGEDQPKQVYVDKLacetylation[1]
674PKQVYVDKLAELRTLacetylation[1]
704KLFEELGKQIQQYMKacetylation[1]
719VISSFKNKEDQYEHLacetylation[1]
733LDAADMTKVEKSTNEacetylation[1]
754SKLNLQNKQSLTADPubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 840 AA 
Protein Sequence
MSVVGIDLGF QSCYVAVARA GGIETIANEY SDRCTPACVS FGPKNRSVGA AAKSQVISNA 60
KNTVQGFKRF HGRAFSDPFV EAEKSNLAYD IVQLPTGLTG IKVTYMEEER NFTTEQVTAM 120
LLSKLKETAE SVLKKPVVDC VVSVPSFYTD AERRSVMDAT QIAGLNCLRL MNETTAVALA 180
YGIYKQDLPA LEEKPRNVVF VDMGHSAYQV SVCAFNRGKL KVLATAFDTT LGGRKFDEVL 240
VNHFCEEFGK KYKLDIKSKV RALLRLSQEC EKLKKLMSAN ASDLPLSIEC FMNDIDVSGT 300
MNRGKFLEMC DDLLARVEPP LRSILDQSKL KKEDIYAVEI VGGATRIPAV KEKISKFFGK 360
ELSTTLNADE AVTRGCALQC AILSPAFKVR EFSITDVVPY PISLRWNSPA EEGSSDCEVF 420
PKNHAAPFSK VLTFYRKEPF TLEAYYSSPQ DLPYPDPAIA QFSVQKVTPQ SDGSSSKVKV 480
KVRVNVHGIF SVSSAALVEV HKSEESEEPM ETDQNAKEEE KMQVDQEEPH TEEQQPQTPA 540
ENKAESEEME TSQAGSKDKK TDQPPQAKKA KVKTSTVDLP IESQLLWQLD REMLGLYTEN 600
EGKMIMQDKL EKERNDAKNA VEEYVYEMRD KLSGEYEKFV SEDDRNNFTL KLEDTENWLY 660
EDGEDQPKQV YVDKLAELRT LGQPIKTRFQ ESEERPKLFE ELGKQIQQYM KVISSFKNKE 720
DQYEHLDAAD MTKVEKSTNE AMEWMNSKLN LQNKQSLTAD PVVKTKEIEA KIKELTNICS 780
PIISKPKPKV EPPKEEPKHA EQNGPVDGQG DNPGTQAAEH GADTAVPSDG DKKLPEMDID 840 
Gene Ontology
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0051131; P:chaperone-mediated protein complex assembly; IEA:Compara.
 GO:0045040; P:protein import into mitochondrial outer membrane; IEA:Compara. 
Interpro
 IPR018181; Heat_shock_70_CS.
 IPR013126; Hsp_70_fam. 
Pfam
 PF00012; HSP70 
SMART
  
PROSITE
 PS00329; HSP70_2
 PS01036; HSP70_3 
PRINTS
 PR00301; HEATSHOCK70.