UniProt Accession

 ARF6_RAT; P62332; P26438; Q5BKA5 

Genbank Protein ID

 L12385; BC091146 

Genbank Nucleotide ID

 AAA40690.1; AAH91146.1 

Protein Name

 ADP-ribosylation factor 6 

Protein Synonyms/Alias

  

Gene Name

 Arf6 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
12	LSKIFGNKEMRILML	acetylation	[1]
131	QDLPDAMKPHEIQEK	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus Contributes to the regulation of dendritic branching and filopodia extension (By similarity). Involved in the regulation of dendritic spine development. 

Sequence Annotation

 NP_BIND 20 27 GTP (By similarity).
 NP_BIND 63 67 GTP (By similarity).
 NP_BIND 122 125 GTP (By similarity).
 LIPID 2 2 N-myristoyl glycine (By similarity).  

Keyword

 Cell membrane; Cell projection; Complete proteome; Differentiation; Endosome; ER-Golgi transport; Golgi apparatus; GTP-binding; Lipoprotein; Membrane; Myristate; Neurogenesis; Nucleotide-binding; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 175 AA 

Protein Sequence

Gene Ontology

 GO:0005938; C:cell cortex; IEA:Compara.
 GO:0005769; C:early endosome; IDA:RGD.
 GO:0030139; C:endocytic vesicle; ISS:UniProtKB.
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0031527; C:filopodium membrane; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:RGD.
 GO:0055037; C:recycling endosome; IDA:RGD.
 GO:0001726; C:ruffle; IDA:RGD.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0030036; P:actin cytoskeleton organization; TAS:RGD.
 GO:0006915; P:apoptotic process; IEA:Compara.
 GO:0030866; P:cortical actin cytoskeleton organization; IEA:Compara.
 GO:0016358; P:dendrite development; TAS:RGD.
 GO:0090162; P:establishment of epithelial cell polarity; IEA:Compara.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0030838; P:positive regulation of actin filament polymerization; IEA:Compara.
 GO:0090004; P:positive regulation of establishment of protein localization to plasma membrane; IEA:Compara.
 GO:0034394; P:protein localization to cell surface; IEA:Compara.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0060998; P:regulation of dendritic spine development; IMP:UniProtKB.
 GO:0051489; P:regulation of filopodium assembly; IEA:Compara.
 GO:0035020; P:regulation of Rac protein signal transduction; IEA:Compara.
 GO:0031529; P:ruffle organization; IEA:Compara.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
 GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR024156; Small_GTPase_ARF.
 IPR006689; Small_GTPase_ARF/SAR. 

Pfam

 PF00025; Arf 

SMART

 SM00177; ARF 

PROSITE

 PS51417; ARF 

PRINTS

 PR00328; SAR1GTPBP.