UniProt Accession

 ACBP_YEAST; P31787; D6VUH4; Q45U46 

Genbank Protein ID

 M99489; Y08687; Y08689; DQ115390; Z72822; BK006941 

Genbank Nucleotide ID

 AAA34384.1; CAA69944.1; CAA69947.1; AAZ22453.1; CAA97025.1; DAA08135.1 

Protein Name

 Acyl-CoA-binding protein 

Protein Synonyms/Alias

 ACBP 

Gene Name

 ACB1 

Gene Synonyms/Alias

 ACB; YGR037C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
19	AVNELPTKPSTDELL	acetylation	[1]
19	AVNELPTKPSTDELL	ubiquitination	[2]
51	KPGIFNMKDRYKWEA	acetylation	[1]
51	KPGIFNMKDRYKWEA	ubiquitination	[3]
55	FNMKDRYKWEAWENL	acetylation	[1]
72	KSQEDAEKEYIALVD	acetylation	[1]
72	KSQEDAEKEYIALVD	ubiquitination	[2, 3]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [3] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 

Functional Description

 Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. 

Sequence Annotation

 DOMAIN 2 87 ACB.
 REGION 29 33 Acyl-CoA binding (By similarity).
 BINDING 51 51 Acyl-CoA (By similarity).
 BINDING 55 55 Acyl-CoA (By similarity).
 BINDING 74 74 Acyl-CoA (By similarity).  

Keyword

 3D-structure; Complete proteome; Lipid-binding; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 87 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005576; C:extracellular region; IMP:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0000062; F:fatty-acyl-CoA binding; ISS:SGD.
 GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
 GO:0005324; F:long-chain fatty acid transporter activity; IMP:SGD.
 GO:0001300; P:chronological cell aging; IMP:SGD. 

Interpro

 IPR022408; Acyl-CoA-binding_prot_CS.
 IPR000582; Acyl-CoA-binding_protein.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx. 

Pfam

 PF00887; ACBP 

SMART

  

PROSITE

 PS00880; ACB_1
 PS51228; ACB_2 

PRINTS

 PR00689; ACOABINDINGP.