CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009993
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Uroporphyrinogen decarboxylase 
Protein Synonyms/Alias
 UPD; URO-D 
Gene Name
 Urod 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
250RVKAGLQKAGLAPVPubiquitination[1]
297KARERVGKAVTLQGNubiquitination[1]
359AFVDAVHKHSRLLRQubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity). 
Sequence Annotation
 REGION 37 41 Substrate binding (By similarity).
 BINDING 55 55 Substrate (By similarity).
 BINDING 85 85 Substrate (By similarity).
 BINDING 86 86 Substrate (By similarity).
 BINDING 164 164 Substrate (By similarity).
 BINDING 219 219 Substrate (By similarity).
 BINDING 339 339 Substrate (By similarity).
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 61 61 Phosphoserine.  
Keyword
 Acetylation; Complete proteome; Cytoplasm; Decarboxylase; Direct protein sequencing; Heme biosynthesis; Lyase; Phosphoprotein; Porphyrin biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 367 AA 
Protein Sequence
MEANGFGLQN FPELKNDTFL RAAWGEETDY TPVWCMRQAG RYLPEFRETR AAQDFFSTCR 60
SPEACCELTL QPLRRFPLDA AIIFSDILVV PQALGMEVTM VPGKGPSFPE PLREERDLER 120
LRDPAAAASE LGYVFQAITL TRQRLAGRVP LIGFAGAPWT LMTYMVEGGS SSTMAQAKRW 180
LYQRPQASHK LLGILTDVLV PYLIGQVAAG AQALQLFESH AGHLGTELFS KFALPYIRDV 240
AKRVKAGLQK AGLAPVPMII FAKDGHFALE ELAQAGYEVV GLDWTVAPKK ARERVGKAVT 300
LQGNLDPCAL YASEEEIGRL VQQMLDDFGP QRYIANLGHG LYPDMDPERV GAFVDAVHKH 360
SRLLRQN 367 
Gene Ontology
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0015630; C:microtubule cytoskeleton; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0004853; F:uroporphyrinogen decarboxylase activity; IDA:MGI.
 GO:0006783; P:heme biosynthetic process; IMP:MGI.
 GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR006361; Uroporphyrinogen_deCO2ase_HemE.
 IPR000257; Uroporphyrinogen_deCOase. 
Pfam
 PF01208; URO-D 
SMART
  
PROSITE
 PS00906; UROD_1
 PS00907; UROD_2 
PRINTS