CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031308
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 FH1/FH2 domain-containing protein 1 
Protein Synonyms/Alias
 cDNA FLJ55372, highly similar to FH1/FH2 domain-containing protein 
Gene Name
 FHOD1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
309FDEFAVSKDGIEKLLubiquitination[1]
497ESLRSLAKHELAPALubiquitination[1, 2]
579RVLQQQQKQATYRERubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 743 AA 
Protein Sequence
MAGGEDRGDG EPVSVVTVRV QYLEDTDPFA CANFPEPRRA PTCSLDGAMP NEAGGHPDAR 60
QLWDSPETAP AARTPQSPAP CVLLRAQRSL APEPKEPLIP ASPKAEPIWE LPTRAPRLSI 120
GDLDFSDLGE DEDQDMLNVE SVEAGKDIPA PSPPLPLLSG VPPPPPLPPP PPIKGPFPPP 180
PPLPLAAPLP HSVPDSSALP TKRKTVKLFW RELKLAGGHG VSASRFGPCA TLWASLDPVS 240
VDTARLEHLF ESRAKEVLPS KKAGEGRRTM TTVLDPKRSN AINIGLTTLP PVHVIKAALL 300
NFDEFAVSKD GIEKLLTMMP TEEERQKIEE AQLANPDIPL GPAENFLMTL ASIGGLAARL 360
QLWAFKLDYD SMEREIAEPL FDLKVGMEQL VQNATFRCIL ATLLAVGNFL NGSQSSGFEL 420
SYLEKVSEVK DTVRRQSLLH HLCSLVLQTR PESSDLYSEI PALTRCAKVD FEQLTENLGQ 480
LERRSRAAEE SLRSLAKHEL APALRARLTH FLDQCARRVA MLRIVHRRVC NRFHAFLLYL 540
GYTPQAAREV RIMQFCHTLR EFALEYRTCR ERVLQQQQKQ ATYRERNKTR GRMITETEKF 600
SGVAGEAPSN PSVPVAVSSG PGRGDADSHA SMKSLLTSRP EDTTHNRRSR GMVQSSSPIM 660
PTVGPSTASP EEPPGSSLPS DTSDEIMDLL VQSVTKSSPR ALAARERKRS RGNRKSLRRT 720
LKSGLGDDLV QALGLSKGPG LEV 743 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0030036; P:actin cytoskeleton organization; IEA:InterPro. 
Interpro
 IPR003104; Actin-bd_FH2/DRF_autoreg.
 IPR015425; FH2_actin-bd. 
Pfam
 PF02181; FH2 
SMART
 SM00498; FH2 
PROSITE
 PS51444; FH2 
PRINTS